Gene Details:

• Gene ID: ACHR01010422.1
• Gene Symbol: CsHMA4
• Gene Name: heavy metal ATPase4
• Genome: The genome of cucumber (ACHR0100000)(https://www.ncbi.nlm.nih.gov/nuccore/ACHR00000000.1)
• Species: Cucumis sativus

Functional Descriptions:

• CsHMA3 was predominantly expressed in roots and up-regulated by Pb, Zn and Cd excess, whereas the CsHMA4 transcript was most abundant in roots and flowers of cucumber plants, and elevated under Pb and Zn excess.
• Expression of CsHMA3 in Saccharomyces cerevisiae enhanced yeast tolerance to Cd and Pb, whereas CsHMA4 conferred increased resistance of yeast cells to Cd and Zn.
• Immunostaining with specific antibodies raised against cucumber proteins revealed tonoplast localization of CsHMA3 and plasma membrane localization of CsHMA4 in cucumber root cells.
• Altogether, the results suggest an important role of CsHMA3 and CsHMA4 in Cd and Pb detoxification and Zn homeostasis in cucumber cells.

Function-related keywords:

• root ,  resistance ,  tolerance ,  homeostasis ,  plasma-membrane ,  detoxification

Literature:

• Molecular and biochemical properties of two P1B2-ATPases, CsHMA3 and CsHMA4, from cucumber.   DOI:  10.1111/pce.12447 ;  PMID:  25210955

Related News:

Gene Resources:

• NCBI ID: KJ818258
• UniProt accessions:

Orthologs:

Sequences:

• CDS Sequence:
• Protein Sequence: