Gene Details:

  • Gene ID: Seita.9G180100
  • Gene Symbol: SiGFT1
  • Gene Name: glutamate formiminotransferase 1
  • Genome:
  • Species: Setaria italica

Functional Descriptions:

  • Nullification of GFTs fortifies bioactive folates in foxtail millet.
  • Two plants harbored a 1-bp insertion (#1) and a 6-bp deletion (#8), in the second exon of SiGFT1, leading to a premature termination of translation or deletion of two amino acids, respectively.
  • The two other knockout plants carried a 1-bp insertion in SiGFT1 and a 2,946-bp deletion between the two sgRNAs that removed part of SiGFT2 (#11) and a 1-bp insertion in both SiGFT1 and SiGFT2 (#13); both combinations were predicted to successfully inactivate SiGFT1 and SiGFT2 simultaneously.
  • SiGFT1, are essential for MeFox biosynthesis in vivo, offering a means to block MeFox formation in vivo by genetically inactivating SiGFTs.

Literature:

Gene Resources:

  • NCBI ID:
  • UniProt accessions:

Orthologs:

Sequences:

  • CDS Sequence:
  • Protein Sequence: