Gene Details:

• Gene ID: AT2G43360
• Gene Symbol: BIO2, BIOB, EMB49
• Gene Name: BIOTIN AUXOTROPH 2, BIOTIN AUXOTROPH B,
• Description: Radical SAM superfamily protein;(source:Araport11)
• TAIR Accession: locus:2005497
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT2G43360.1

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
• PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

• GO:0009102  — acts upstream of or within — biotin biosynthetic process
• GO:0009102  — involved in — biotin biosynthetic process
• GO:0004076  — enables — biotin synthase activity
• GO:0051537  — enables — 2 iron, 2 sulfur cluster binding
• GO:0005739  — located in — mitochondrion
• GO:0008270  — enables — zinc ion binding

Germplasm Phenotype:

• CS6329  — developmental arrest of mutant embryos occurs at transition, globular-heart-elongate (early linear) stage ; pale yellow-green seeds; white to pale yellow-green embryo; 26% mutant; 48% aborted seeds in top half of silique.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  root ,  shoot system ,  plant embryo ,  vascular leaf ,  stamen ,  sepal ,  flower ,  inflorescence flower pedicel ,  cotyledon ,  petiole ,  hypocotyl ,  leaf apex ,  collective leaf structure ,  pollen

Literature:

• An embryo-defective mutant of arabidopsis disrupted in the final step of biotin synthesis.   DOI:  10.1104/pp.116.3.935 ;  PMID:  9501126
• Biotin synthesis in higher plants: purification and characterization of bioB gene product equivalent from Arabidopsis thaliana overexpressed in Escherichia coli and its subcellular localization in pea leaf cells.   DOI:  10.1016/s0014-5793(97)01458-0 ;  PMID:  9428635
• Biotin synthase from Arabidopsis thaliana. cDNA isolation and characterization of gene expression.   DOI:  10.1104/pp.112.1.371 ;  PMID:  8819333
• Characterization of the cDNA and gene coding for the biotin synthase of Arabidopsis thaliana.   DOI:  10.1104/pp.110.3.1021 ;  PMID:  8819873
• Biotin synthesis in higher plants: isolation of a cDNA encoding Arabidopsis thaliana bioB-gene product equivalent by functional complementation of a biotin auxotroph mutant bioB105 of Escherichia coli K12.   DOI:  NA ;  PMID:  8680961
• Biochemical characterization of the Arabidopsis biotin synthase reaction. The importance of mitochondria in biotin synthesis.   DOI:  6899 ;  PMID:  11706201
• The plant biotin synthase reaction. Identification and characterization of essential mitochondrial accessory protein components.   DOI:  10.1074/jbc.M302154200 ;  PMID:  12714594
• Isolation, sequence analysis, and expression studies of florally expressed cDNAs in Arabidopsis.   DOI:  10.1023/B:PLAN.0000019063.18097.62 ;  PMID:  15010618
• The Arabidopsis Bio2 protein requires mitochondrial targeting for activity.   DOI:  10.1007/s11103-006-9034-x ;  PMID:  16897469
• A bifunctional locus (BIO3-BIO1) required for biotin biosynthesis in Arabidopsis.   DOI:  10.1104/pp.107.107409 ;  PMID:  17993549
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function.   DOI:  10.1104/pp.109.147942 ;  PMID:  20018591
• SUCROSE TRANSPORTER 5 supplies Arabidopsis embryos with biotin and affects triacylglycerol accumulation.   DOI:  10.1111/tpj.12037 ;  PMID:  23031218
• Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis.   DOI:  10.1111/nph.16071 ;  PMID:  31334862
• Biotin plays an important role in Arabidopsis thaliana seedlings under carbonate stress.   DOI:  10.1016/j.plantsci.2020.110639 ;  PMID:  33180716
• The function of glutaredoxin GRXS15 is required for lipoyl-dependent dehydrogenases in mitochondria.   DOI:  10.1093/plphys/kiab172 ;  PMID:  33856472
• Characterization of the cDNA and gene coding for the biotin synthase of Arabidopsis thaliana.   DOI:  10.1104/pp.110.3.1021 ;  PMID:  8819873
• Biotin synthesis in higher plants: isolation of a cDNA encoding Arabidopsis thaliana bioB-gene product equivalent by functional complementation of a biotin auxotroph mutant bioB105 of Escherichia coli K12.   DOI:  NA ;  PMID:  8680961

Sequence: