Gene Details:
- Gene ID: AT3G18110
- Gene Symbol: ACM1, EMB1270
- Gene Name: Albino Cotyledon Mutant1, embryo defective 1270
- Description: Pentatricopeptide repeat (PPR) superfamily protein;(source:Araport11)
- TAIR Accession: locus:2092712
- Genome: Araport11_genome_release
- Species: Arabidopsis thaliana
Transcripts:
Gene Ontology:
- GO:0009534 — located in — chloroplast thylakoid
- GO:0009507 — located in — chloroplast
- GO:0009793 — acts upstream of or within — embryo development ending in seed dormancy
- GO:0009570 — located in — chloroplast stroma
- GO:0003729 — enables — mRNA binding
- GO:0031425 — acts upstream of or within — chloroplast RNA processing
- GO:0003723 — enables — RNA binding
- GO:0005515 — enables — protein binding
Germplasm Phenotype:
- CS16015 — Embryo defective; initiated cotyledons and continued growth and cell division beyond heart stage. Embryos elongated and developed a clear hypocotyl, but featured dramatically stunted cotyledons. Domed shoot apex.
- CS16015 — embryo defective; developmental arrest of mutant embryos
- SAIL_896_E10 — Albino cotyledons. In heterozygous acm1/+ siliques, some of the ovules were white, segregating 1:3 for white:green.
- emb1270-1 — Embryo/seedling lethal. Mutant embryos can be cultured on sucrose containing MS media but they produce albino leaves and then die.
Literature:
- Inactivation of the chloroplast ATP synthase gamma subunit results in high non-photochemical fluorescence quenching and altered nuclear gene expression in Arabidopsis thaliana. DOI: 10.1074/jbc.M308435200 ; PMID: 14576160
- Genome-wide analysis of Arabidopsis pentatricopeptide repeat proteins reveals their essential role in organelle biogenesis. DOI: 10.1105/tpc.104.022236 ; PMID: 15269332
- Identification of genes required for embryo development in Arabidopsis. DOI: 10.1104/pp.104.045179 ; PMID: 15266054
- Arabidopsis emb175 and other ppr knockout mutants reveal essential roles for pentatricopeptide repeat (PPR) proteins in plant embryogenesis. DOI: 10.1007/s00425-004-1452-x ; PMID: 15647901
- Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection. DOI: 10.1104/pp.108.121038 ; PMID: 18650403
- Genome-wide identification of EMBRYO-DEFECTIVE (EMB) genes required for growth and development in Arabidopsis. DOI: 10.1111/nph.16071 ; PMID: 31334862
- Arabidopsis emb175 and other ppr knockout mutants reveal essential roles for pentatricopeptide repeat (PPR) proteins in plant embryogenesis. DOI: 10.1007/s00425-004-1452-x ; PMID: 15647901
Sequence:
cDNA Sequence
- >AT3G18110.1 GTTTGTTTCTCACTTTCTCAGGAACCTTAAAAGATCACTCTTCTCTTTCACTCGCTTCTCATCTTTTAACGGTACAACGAAATTTATGAAGCTGAGAGAAGAAGACATTAATGGCGGTTTCTGCAGGGGCTTTAGCTTTTCCTGCTTTATCCGTTCGCGCCACTCTTAATCCTGAGATTAAAGATGAACAAGCGAACATCAGCAGCACTACTTCTTCTTCCCAGAAATTCACTTACAGTCGAGCTTCTCCCGCCGTCCGATGGCCACATTTGAATCTCCGTGAGATTTATGATTCCACACCTTCACAAACTCTTTCTTCTCCGGTTTCTCCCATCGCCGGTACACCGGATTCAGGTGATGTCGTCGATTCAATTGCCTCCCGCGAGGAGCAAAAGACGAAAGATGAAACCGCCGTGGCGACTCGGAGAAGGAGAGTGAAGAAGATGAATAAAGTGGCGTTGATTAAGGCTAAAGACTGGAGAGAGAGAGTCAAATTTCTGACGGATAAGATTCTAAGCTTGAAATCTAATCAGTTCGTTGCTGATATTCTCGATGCTCGTCTTGTTCAGATGACTCCTACTGATTACTGCTTCGTCGTGAAATCAGTTGGTCAAGAGAGTTGGCAACGAGCTCTTGAGGTTTTTGAGTGGCTCAATCTCCGTCATTGGCACTCTCCTAACGCTCGGATGGTGGCTGCTATACTCGGTGTTTTGGGACGGTGGAATCAGGAATCCCTTGCGGTGGAGATTTTCACTAGGGCTGAGCCAACCGTCGGAGATAGGGTTCAGGTGTACAACGCAATGATGGGGGTTTATTCACGTAGTGGTAAGTTTTCGAAAGCACAAGAGCTGGTCGATGCAATGCGTCAGAGAGGGTGTGTTCCAGATCTTATTAGTTTCAATACTCTTATCAACGCTAGGCTTAAATCTGGTGGGTTGACTCCGAATTTGGCTGTTGAGTTATTAGATATGGTGAGGAATTCGGGTCTTAGGCCTGATGCTATCACTTACAACACTCTTCTTAGTGCCTGTTCGCGGGATTCGAATTTGGATGGTGCAGTGAAGGTTTTTGAGGATATGGAAGCTCATCGGTGTCAGCCTGATTTGTGGACTTATAATGCTATGATTTCTGTTTATGGAAGATGTGGGCTTGCTGCTGAAGCTGAGAGGCTCTTCATGGAGCTGGAGCTTAAAGGTTTTTTCCCTGATGCAGTGACATACAACTCTTTGCTGTATGCGTTTGCCAGAGAAAGAAATACGGAGAAGGTGAAGGAGGTGTACCAACAGATGCAGAAAATGGGGTTTGGGAAAGATGAGATGACATACAACACGATCATTCACATGTATGGCAAGCAGGGACAACTTGATCTTGCGCTACAGCTTTATAAGGACATGAAAGGTTTGTCGGGTAGGAACCCTGATGCTATTACTTACACTGTTTTGATCGATTCTCTTGGAAAAGCAAACCGAACAGTGGAAGCCGCAGCTTTAATGTCTGAGATGCTTGATGTTGGGATCAAACCAACTCTGCAGACATACAGTGCTCTTATCTGTGGTTATGCCAAGGCTGGAAAGCGAGAGGAGGCTGAGGATACTTTCAGTTGCATGTTGCGCTCAGGCACTAAACCTGATAATTTAGCGTATTCTGTAATGTTGGATGTATTACTAAGAGGCAACGAGACAAGAAAGGCCTGGGGTTTATACCGTGATATGATTTCTGATGGTCATACACCGTCTTACACTCTGTATGAGTTGATGATACTTGGACTTATGAAGGAAAACAGGTCAGATGACATTCAGAAAACCATCAGAGACATGGAAGAATTGTGTGGCATGAACCCACTAGAGATTTCATCAGTGCTTGTTAAGGGCGAATGCTTTGATCTCGCTGCTAGACAGTTGAAAGTGGCTATCACCAATGGCTATGAATTGGAAAACGACACTCTATTGTCTATCCTGGGTTCCTATAGTTCATCAGGCAGGCATTCAGAAGCGTTTGAGTTACTTGAATTTTTGAAAGAGCATGCCAGTGGATCTAAAAGACTTATAACTGAAGCTCTAATTGTTCTACATTGCAAGGTGAACAACTTAAGCGCTGCTCTAGATGAATATTTCGCTGACCCATGTGTTCATGGCTGGTGTTTTGGCAGTTCCACCATGTATGAGACTCTATTACACTGCTGTGTAGCAAATGAACATTATGCTGAAGCTTCTCAGGTTTTCTCTGACCTGAGACTATCTGGCTGCGAAGCTTCAGAAAGTGTTTGTAAAAGCATGGTTGTTGTGTATTGCAAGCTTGGCTTTCCAGAGACAGCTCATCAAGTGGTTAATCAGGCTGAGACAAAAGGCTTCCACTTTGCTTGTTCGCCTATGTATACTGATATCATTGAGGCTTATGGAAAACAAAAACTATGGCAGAAAGCGGAGAGTGTGGTTGGCAACCTAAGACAAAGTGGACGAACACCTGATCTGAAGACATGGAACAGCTTGATGTCGGCTTATGCTCAGTGTGGCTGTTACGAGCGGGCAAGGGCTATTTTTAACACTATGATGAGGGATGGTCCGTCTCCTACTGTTGAATCCATCAATATTTTGTTGCATGCTTTGTGTGTTGATGGGAGACTCGAGGAGCTCTACGTTGTTGTTGAAGAATTGCAAGATATGGGCTTTAAGATTAGCAAAAGCTCCATTCTCTTGATGCTTGACGCATTTGCCCGAGCTGGAAATATCTTTGAGGTAAAGAAGATATACAGTAGCATGAAAGCTGCTGGTTACTTACCCACAATCCGCCTTTATAGGATGATGATTGAGCTTCTCTGCAAAGGGAAACGAGTTAGAGATGCTGAAATTATGGTCTCTGAAATGGAAGAGGCCAATTTCAAGGTTGAGCTTGCTATATGGAATTCCATGCTGAAGATGTATACGGCTATCGAGGATTACAAGAAGACAGTTCAAGTATACCAGAGGATAAAAGAAACTGGACTGGAACCAGACGAGACCACTTACAATACTCTGATTATAATGTATTGTAGAGACAGACGACCAGAAGAAGGGTACTTGCTTATGCAGCAAATGAGAAATCTTGGTTTGGACCCAAAACTGGACACATACAAGAGCTTGATCTCTGCTTTTGGTAAGCAAAAATGCCTTGAACAAGCTGAACAACTGTTTGAAGAGCTTCTCTCAAAAGGTTTGAAACTAGACCGTTCATTTTACCACACAATGATGAAAATATCCCGAGATTCTGGAAGCGACTCCAAGGCAGAGAAGTTATTGCAAATGATGAAGAATGCGGGAATAGAACCAACACTTGCTACAATGCATCTGCTTATGGTTTCATATAGTTCTTCAGGAAATCCCCAAGAAGCTGAAAAAGTTCTTAGTAACCTGAAAGACACAGAAGTGGAACTAACAACTCTGCCTTATAGTTCAGTTATTGATGCTTACCTTCGGAGCAAAGATTATAACAGTGGAATAGAAAGGCTTTTGGAAATGAAGAAAGAGGGCCTAGAGCCAGACCACAGGATATGGACTTGCTTTGTTAGGGCGGCGAGTTTCTCCAAGGAAAAAATTGAAGTCATGTTGCTGCTTAAAGCTCTTGAAGATATTGGTTTTGATCTTCCTATCAGGCTTTTAGCTGGAAGACCTGAGTTGCTAGTTTCTGAGGTGGATGGATGGTTCGAGAAACTGAAATCCATAGAGGACAATGCTGCTCTCAATTTTGTTAATGCTCTTTTGAATCTTCTCTGGGCGTTTGAACTCAGAGCTACTGCATCATGGGTTTTCCAATTGGGAATCAAAAGGGGTATCTTCAGTCTCGATGTTTTTAGGGTGGCGGACAAGGACTGGGGTGCGGATTTCAGAAGGCTGTCTGGAGGTGCAGCACTTGTTGCCCTGACGCTATGGCTTGACCACATGCAGGATGCATCACTGGAAGGCTACCCAGAGTCTCCAAAGTCAGTTGTCTTAATCACAGGGACCGCAGAGTACAACGGTATATCCCTTGATAAAACGCTAAAGGCGTGTCTTTGGGAAATGGGTTCTCCATTTCTTCCCTGCAAGACGAGAACGGGACTGCTAGTGGCCAAAGCTCACTCTCTCAGAATGTGGTTGAAGGACTCGCCGTTCTGCTTCGACTTGGAGCTAAAAGACTCGGTGTCTTTACCAGAATCAAACTCGATGGACCTGATTGACGGGTGTTTCATAAGACGTGGACTTGTTCCTGCGTTTAACCACATCAAAGAGAGACTTGGTGGATTTGTGTCACCAAAGAAGTTTTCGAGACTGGCGTTGCTACCAGACGAGATGAGAGAGCGAGTGATAAAGACAGATATTGAAGGACATAGACAGAAGTTAGAGAAGATGAAGAAGAAGAAAATGGGCAATGAAACGAATGGTATTAACACTCGAAGGAAGTTCGTCAGAAGCAAGTGATGTCATGATATTGTACTCTCTTATTATAAAATCTCATTAGTGATTATTTGTATACAGACAGTTTTGATTTTCCTCTTTGTGGATACTAATTAGAATAAGTGTTCATGTAATATTTATCGATAGGGTTTAGTAAATTAAACAGAGCTATTGCGTCTAACAACCTTTTACCGTGAACGAAAAAAAATGTAATGCATTCAACTACTCTTTCTACCAATGCCTAGTTCAACTTATTTATTGTTGAGTTCAAGATTTTTGTTGTCGTTGTTGTTAGAATCAGTGACTATTCTAAAGATGTTTGGATTACACATATTTATACATACAATAAATTTCAAAATTTTCAAGAGCCAAAAAAACAACTAATTTGGTGCATCTTGGTTCTTAATAGGAACAACTGCAGATATTTTCCTTCTCCTAGGCGTAAGTTTTTTTAAACCAGTGGTGTTGTTAGATGTTTCTGCAACACTTTTGCGTCTTCGTTTTCGTTTCTCCTTTGCATTGTCTTGGATCTCGT
CDS Sequence
- >AT3G18110.1 ATGGCGGTTTCTGCAGGGGCTTTAGCTTTTCCTGCTTTATCCGTTCGCGCCACTCTTAATCCTGAGATTAAAGATGAACAAGCGAACATCAGCAGCACTACTTCTTCTTCCCAGAAATTCACTTACAGTCGAGCTTCTCCCGCCGTCCGATGGCCACATTTGAATCTCCGTGAGATTTATGATTCCACACCTTCACAAACTCTTTCTTCTCCGGTTTCTCCCATCGCCGGTACACCGGATTCAGGTGATGTCGTCGATTCAATTGCCTCCCGCGAGGAGCAAAAGACGAAAGATGAAACCGCCGTGGCGACTCGGAGAAGGAGAGTGAAGAAGATGAATAAAGTGGCGTTGATTAAGGCTAAAGACTGGAGAGAGAGAGTCAAATTTCTGACGGATAAGATTCTAAGCTTGAAATCTAATCAGTTCGTTGCTGATATTCTCGATGCTCGTCTTGTTCAGATGACTCCTACTGATTACTGCTTCGTCGTGAAATCAGTTGGTCAAGAGAGTTGGCAACGAGCTCTTGAGGTTTTTGAGTGGCTCAATCTCCGTCATTGGCACTCTCCTAACGCTCGGATGGTGGCTGCTATACTCGGTGTTTTGGGACGGTGGAATCAGGAATCCCTTGCGGTGGAGATTTTCACTAGGGCTGAGCCAACCGTCGGAGATAGGGTTCAGGTGTACAACGCAATGATGGGGGTTTATTCACGTAGTGGTAAGTTTTCGAAAGCACAAGAGCTGGTCGATGCAATGCGTCAGAGAGGGTGTGTTCCAGATCTTATTAGTTTCAATACTCTTATCAACGCTAGGCTTAAATCTGGTGGGTTGACTCCGAATTTGGCTGTTGAGTTATTAGATATGGTGAGGAATTCGGGTCTTAGGCCTGATGCTATCACTTACAACACTCTTCTTAGTGCCTGTTCGCGGGATTCGAATTTGGATGGTGCAGTGAAGGTTTTTGAGGATATGGAAGCTCATCGGTGTCAGCCTGATTTGTGGACTTATAATGCTATGATTTCTGTTTATGGAAGATGTGGGCTTGCTGCTGAAGCTGAGAGGCTCTTCATGGAGCTGGAGCTTAAAGGTTTTTTCCCTGATGCAGTGACATACAACTCTTTGCTGTATGCGTTTGCCAGAGAAAGAAATACGGAGAAGGTGAAGGAGGTGTACCAACAGATGCAGAAAATGGGGTTTGGGAAAGATGAGATGACATACAACACGATCATTCACATGTATGGCAAGCAGGGACAACTTGATCTTGCGCTACAGCTTTATAAGGACATGAAAGGTTTGTCGGGTAGGAACCCTGATGCTATTACTTACACTGTTTTGATCGATTCTCTTGGAAAAGCAAACCGAACAGTGGAAGCCGCAGCTTTAATGTCTGAGATGCTTGATGTTGGGATCAAACCAACTCTGCAGACATACAGTGCTCTTATCTGTGGTTATGCCAAGGCTGGAAAGCGAGAGGAGGCTGAGGATACTTTCAGTTGCATGTTGCGCTCAGGCACTAAACCTGATAATTTAGCGTATTCTGTAATGTTGGATGTATTACTAAGAGGCAACGAGACAAGAAAGGCCTGGGGTTTATACCGTGATATGATTTCTGATGGTCATACACCGTCTTACACTCTGTATGAGTTGATGATACTTGGACTTATGAAGGAAAACAGGTCAGATGACATTCAGAAAACCATCAGAGACATGGAAGAATTGTGTGGCATGAACCCACTAGAGATTTCATCAGTGCTTGTTAAGGGCGAATGCTTTGATCTCGCTGCTAGACAGTTGAAAGTGGCTATCACCAATGGCTATGAATTGGAAAACGACACTCTATTGTCTATCCTGGGTTCCTATAGTTCATCAGGCAGGCATTCAGAAGCGTTTGAGTTACTTGAATTTTTGAAAGAGCATGCCAGTGGATCTAAAAGACTTATAACTGAAGCTCTAATTGTTCTACATTGCAAGGTGAACAACTTAAGCGCTGCTCTAGATGAATATTTCGCTGACCCATGTGTTCATGGCTGGTGTTTTGGCAGTTCCACCATGTATGAGACTCTATTACACTGCTGTGTAGCAAATGAACATTATGCTGAAGCTTCTCAGGTTTTCTCTGACCTGAGACTATCTGGCTGCGAAGCTTCAGAAAGTGTTTGTAAAAGCATGGTTGTTGTGTATTGCAAGCTTGGCTTTCCAGAGACAGCTCATCAAGTGGTTAATCAGGCTGAGACAAAAGGCTTCCACTTTGCTTGTTCGCCTATGTATACTGATATCATTGAGGCTTATGGAAAACAAAAACTATGGCAGAAAGCGGAGAGTGTGGTTGGCAACCTAAGACAAAGTGGACGAACACCTGATCTGAAGACATGGAACAGCTTGATGTCGGCTTATGCTCAGTGTGGCTGTTACGAGCGGGCAAGGGCTATTTTTAACACTATGATGAGGGATGGTCCGTCTCCTACTGTTGAATCCATCAATATTTTGTTGCATGCTTTGTGTGTTGATGGGAGACTCGAGGAGCTCTACGTTGTTGTTGAAGAATTGCAAGATATGGGCTTTAAGATTAGCAAAAGCTCCATTCTCTTGATGCTTGACGCATTTGCCCGAGCTGGAAATATCTTTGAGGTAAAGAAGATATACAGTAGCATGAAAGCTGCTGGTTACTTACCCACAATCCGCCTTTATAGGATGATGATTGAGCTTCTCTGCAAAGGGAAACGAGTTAGAGATGCTGAAATTATGGTCTCTGAAATGGAAGAGGCCAATTTCAAGGTTGAGCTTGCTATATGGAATTCCATGCTGAAGATGTATACGGCTATCGAGGATTACAAGAAGACAGTTCAAGTATACCAGAGGATAAAAGAAACTGGACTGGAACCAGACGAGACCACTTACAATACTCTGATTATAATGTATTGTAGAGACAGACGACCAGAAGAAGGGTACTTGCTTATGCAGCAAATGAGAAATCTTGGTTTGGACCCAAAACTGGACACATACAAGAGCTTGATCTCTGCTTTTGGTAAGCAAAAATGCCTTGAACAAGCTGAACAACTGTTTGAAGAGCTTCTCTCAAAAGGTTTGAAACTAGACCGTTCATTTTACCACACAATGATGAAAATATCCCGAGATTCTGGAAGCGACTCCAAGGCAGAGAAGTTATTGCAAATGATGAAGAATGCGGGAATAGAACCAACACTTGCTACAATGCATCTGCTTATGGTTTCATATAGTTCTTCAGGAAATCCCCAAGAAGCTGAAAAAGTTCTTAGTAACCTGAAAGACACAGAAGTGGAACTAACAACTCTGCCTTATAGTTCAGTTATTGATGCTTACCTTCGGAGCAAAGATTATAACAGTGGAATAGAAAGGCTTTTGGAAATGAAGAAAGAGGGCCTAGAGCCAGACCACAGGATATGGACTTGCTTTGTTAGGGCGGCGAGTTTCTCCAAGGAAAAAATTGAAGTCATGTTGCTGCTTAAAGCTCTTGAAGATATTGGTTTTGATCTTCCTATCAGGCTTTTAGCTGGAAGACCTGAGTTGCTAGTTTCTGAGGTGGATGGATGGTTCGAGAAACTGAAATCCATAGAGGACAATGCTGCTCTCAATTTTGTTAATGCTCTTTTGAATCTTCTCTGGGCGTTTGAACTCAGAGCTACTGCATCATGGGTTTTCCAATTGGGAATCAAAAGGGGTATCTTCAGTCTCGATGTTTTTAGGGTGGCGGACAAGGACTGGGGTGCGGATTTCAGAAGGCTGTCTGGAGGTGCAGCACTTGTTGCCCTGACGCTATGGCTTGACCACATGCAGGATGCATCACTGGAAGGCTACCCAGAGTCTCCAAAGTCAGTTGTCTTAATCACAGGGACCGCAGAGTACAACGGTATATCCCTTGATAAAACGCTAAAGGCGTGTCTTTGGGAAATGGGTTCTCCATTTCTTCCCTGCAAGACGAGAACGGGACTGCTAGTGGCCAAAGCTCACTCTCTCAGAATGTGGTTGAAGGACTCGCCGTTCTGCTTCGACTTGGAGCTAAAAGACTCGGTGTCTTTACCAGAATCAAACTCGATGGACCTGATTGACGGGTGTTTCATAAGACGTGGACTTGTTCCTGCGTTTAACCACATCAAAGAGAGACTTGGTGGATTTGTGTCACCAAAGAAGTTTTCGAGACTGGCGTTGCTACCAGACGAGATGAGAGAGCGAGTGATAAAGACAGATATTGAAGGACATAGACAGAAGTTAGAGAAGATGAAGAAGAAGAAAATGGGCAATGAAACGAATGGTATTAACACTCGAAGGAAGTTCGTCAGAAGCAAGTGA
Protein Sequence
- >AT3G18110.1 MAVSAGALAFPALSVRATLNPEIKDEQANISSTTSSSQKFTYSRASPAVRWPHLNLREIYDSTPSQTLSSPVSPIAGTPDSGDVVDSIASREEQKTKDETAVATRRRRVKKMNKVALIKAKDWRERVKFLTDKILSLKSNQFVADILDARLVQMTPTDYCFVVKSVGQESWQRALEVFEWLNLRHWHSPNARMVAAILGVLGRWNQESLAVEIFTRAEPTVGDRVQVYNAMMGVYSRSGKFSKAQELVDAMRQRGCVPDLISFNTLINARLKSGGLTPNLAVELLDMVRNSGLRPDAITYNTLLSACSRDSNLDGAVKVFEDMEAHRCQPDLWTYNAMISVYGRCGLAAEAERLFMELELKGFFPDAVTYNSLLYAFARERNTEKVKEVYQQMQKMGFGKDEMTYNTIIHMYGKQGQLDLALQLYKDMKGLSGRNPDAITYTVLIDSLGKANRTVEAAALMSEMLDVGIKPTLQTYSALICGYAKAGKREEAEDTFSCMLRSGTKPDNLAYSVMLDVLLRGNETRKAWGLYRDMISDGHTPSYTLYELMILGLMKENRSDDIQKTIRDMEELCGMNPLEISSVLVKGECFDLAARQLKVAITNGYELENDTLLSILGSYSSSGRHSEAFELLEFLKEHASGSKRLITEALIVLHCKVNNLSAALDEYFADPCVHGWCFGSSTMYETLLHCCVANEHYAEASQVFSDLRLSGCEASESVCKSMVVVYCKLGFPETAHQVVNQAETKGFHFACSPMYTDIIEAYGKQKLWQKAESVVGNLRQSGRTPDLKTWNSLMSAYAQCGCYERARAIFNTMMRDGPSPTVESINILLHALCVDGRLEELYVVVEELQDMGFKISKSSILLMLDAFARAGNIFEVKKIYSSMKAAGYLPTIRLYRMMIELLCKGKRVRDAEIMVSEMEEANFKVELAIWNSMLKMYTAIEDYKKTVQVYQRIKETGLEPDETTYNTLIIMYCRDRRPEEGYLLMQQMRNLGLDPKLDTYKSLISAFGKQKCLEQAEQLFEELLSKGLKLDRSFYHTMMKISRDSGSDSKAEKLLQMMKNAGIEPTLATMHLLMVSYSSSGNPQEAEKVLSNLKDTEVELTTLPYSSVIDAYLRSKDYNSGIERLLEMKKEGLEPDHRIWTCFVRAASFSKEKIEVMLLLKALEDIGFDLPIRLLAGRPELLVSEVDGWFEKLKSIEDNAALNFVNALLNLLWAFELRATASWVFQLGIKRGIFSLDVFRVADKDWGADFRRLSGGAALVALTLWLDHMQDASLEGYPESPKSVVLITGTAEYNGISLDKTLKACLWEMGSPFLPCKTRTGLLVAKAHSLRMWLKDSPFCFDLELKDSVSLPESNSMDLIDGCFIRRGLVPAFNHIKERLGGFVSPKKFSRLALLPDEMRERVIKTDIEGHRQKLEKMKKKKMGNETNGINTRRKFVRSK