Gene Details:

• Gene ID: AT3G19150
• Gene Symbol: ACK1, AtKRP6, ICK4, KRP6
• Gene Name: ARABIDOPSIS CDK INHIBITOR 1, KIP-related protein 6
• Description: KIP-related protein 6;(source:Araport11)
• TAIR Accession: locus:2094118
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT3G19150.1     AT3G19150.2     AT3G19150.3

Plant Ontology Annotations:

• PO:0000017  — vascular leaf primordium — leaf primordium (exact), portion of vascular leaf primordium tissue (exact), primordio de hoja (Spanish, exact), vascular leaf primordia (exact, plural), 葉原基 (Japanese, exact)
• PO:0006109  — pith — médula (Spanish, exact), medulla (exact), 髄 (Japanese, exact)
• PO:0020148  — shoot apical meristem — SAM (exact), meristema apical del epiblasto (epiblastema) (Spanish, exact), 茎頂分裂組織 (Japanese, exact), primary shoot meristem (related), promeristem (broad)
• PO:0000245  — degenerate megaspore — megaspora degenerativa (Spanish, exact), 退化大胞子、胞子形成に寄与しない大胞子 (Japanese, exact), Poaceae degenerate megaspore (narrow)
• PO:0006015  — female archesporial cell — célula femenina arquesporial (Spanish, exact), female archesporial initial (exact), 雌胞原細胞 (Japanese, exact), ovule archesporial cell (narrow)
• PO:0009066  — anther — antera (Spanish, exact), 半葯,花粉のう (Japanese, exact), Poaceae anther (narrow), Zea anther (narrow)
• PO:0020019  — megaspore — megaspora (Spanish, exact), 大胞子 (Japanese, exact), macrospore (related), Poaceae megaspore (narrow), Zea megaspore (narrow)
• PO:0020047  — microsporocyte — microsporocito (Spanish, exact), 小胞子母細胞 (Japanese, exact), PMC (related), microspore mother cell (related), pollen mother cell (related), Poaceae microsporocyte (narrow), Zea microsporocyte (narrow)

Gene Ontology:

• GO:0005515  — enables — protein binding
• GO:0005634  — located in — nucleus
• GO:0042023  — acts upstream of or within — DNA endoreduplication
• GO:0004861  — enables — cyclin-dependent protein serine/threonine kinase inhibitor activity
• GO:0030332  — enables — cyclin binding
• GO:0005654  — located in — nucleoplasm
• GO:0019900  — enables — kinase binding
• GO:0001673  — located in — male germ cell nucleus

Function-related keywords:

• vascular leaf primordium ,  pith ,  shoot apical meristem ,  degenerate megaspore ,  female archesporial cell ,  anther ,  megaspore ,  microsporocyte

Literature:

• Genome-wide analysis of core cell cycle genes in Arabidopsis.   DOI:  10.1105/tpc.010445 ;  PMID:  11971144
• Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-associated kinases, including plant-specific B-type cyclin-dependent kinase.   DOI:  10.1016/j.febslet.2005.12.018 ;  PMID:  16376885
• A membrane-bound NAC transcription factor regulates cell division in Arabidopsis.   DOI:  10.1105/tpc.106.043018 ;  PMID:  17098812
• Changes in the gene expression profile of Arabidopsis thaliana after infection with Tobacco etch virus.   DOI:  10.1186/1743-422X-5-92 ;  PMID:  18684336
• Control of plant germline proliferation by SCF(FBL17) degradation of cell cycle inhibitors.   DOI:  10.1038/nature07289 ;  PMID:  18948957
• A population genomics study of the Arabidopsis core cell cycle genes shows the signature of natural selection.   DOI:  10.1105/tpc.109.067017 ;  PMID:  19880799
• Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.   DOI:  10.1038/msb.2010.53 ;  PMID:  20706207
• Phosphorylation of p27(KIP1) homologs KRP6 and 7 by SNF1-related protein kinase-1 links plant energy homeostasis and cell proliferation.   DOI:  10.1111/tpj.12218 ;  PMID:  23617622
• Ectopic expression of Kip-related proteins restrains root-knot nematode-feeding site expansion.   DOI:  10.1111/nph.12255 ;  PMID:  23574394
• Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants.   DOI:  10.1111/pce.12912 ;  PMID:  28103637
• Arabidopsis ICK/KRP cyclin-dependent kinase inhibitors function to ensure the formation of one megaspore mother cell and one functional megaspore per ovule.   DOI:  10.1371/journal.pgen.1007230 ;  PMID:  29513662
• Multiple mechanisms explain how reduced KRP expression increases leaf size of Arabidopsis thaliana.   DOI:  10.1111/nph.15458 ;  PMID:  30267580
• Analysis of the spatial expression pattern of seven Kip related proteins (KRPs) in the shoot apex of Arabidopsis thaliana.   DOI:  10.1093/aob/mch077 ;  PMID:  15037450
• Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for plant cell cycle control.   DOI:  10.1111/j.1365-313X.2004.02319.x ;  PMID:  15686519
• Arabidopsis KRPs have distinct inhibitory activity toward cyclin D2-associated kinases, including plant-specific B-type cyclin-dependent kinase.   DOI:  10.1016/j.febslet.2005.12.018 ;  PMID:  16376885
• Arabidopsis cyclin-dependent kinase inhibitors are nuclear-localized and show different localization patterns within the nucleoplasm.   DOI:  10.1007/s00299-006-0294-3 ;  PMID:  17253089
• Targeted degradation of the cyclin-dependent kinase inhibitor ICK4/KRP6 by RING-type E3 ligases is essential for mitotic cell cycle progression during Arabidopsis gametogenesis.   DOI:  10.1105/tpc.108.059741 ;  PMID:  18552199
• Global analysis of the core cell cycle regulators of Arabidopsis identifies novel genes, reveals multiple and highly specific profiles of expression and provides a coherent model for plant cell cycle control.   DOI:  10.1111/j.1365-313X.2004.02319.x ;  PMID:  15686519

Sequence: