Gene Details:

• Gene ID: AT4G17880
• Gene Symbol: MYC4
• Gene Name:
• Description: Basic helix-loop-helix (bHLH) DNA-binding family protein;(source:Araport11)
• TAIR Accession: locus:2141055
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT4G17880.1

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)

Gene Ontology:

• GO:0003700  — enables — DNA-binding transcription factor activity
• GO:0005515  — enables — protein binding
• GO:0006355  — involved in — regulation of DNA-templated transcription
• GO:0000976  — enables — transcription cis-regulatory region binding
• GO:0106167  — acts upstream of or within — extracellular ATP signaling
• GO:2000652  — acts upstream of or within — regulation of secondary cell wall biogenesis
• GO:0045893  — acts upstream of or within — positive regulation of DNA-templated transcription
• GO:0043425  — enables — bHLH transcription factor binding
• GO:0006952  — acts upstream of or within — defense response
• GO:0006355  — acts upstream of or within — regulation of DNA-templated transcription
• GO:0005634  — located in — nucleus
• GO:0046983  — enables — protein dimerization activity
• GO:0010374  — acts upstream of or within — stomatal complex development
• GO:0009718  — acts upstream of or within — anthocyanin-containing compound biosynthetic process
• GO:0005634  — is active in — nucleus

Function-related keywords:

• root

Literature:

• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) function as transcriptional activators in abscisic acid signaling.   DOI:  10.1105/tpc.006130 ;  PMID:  12509522
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534
• The Arabidopsis basic/helix-loop-helix transcription factor family.   DOI:  10.1105/tpc.013839 ;  PMID:  12897250
• Update on the basic helix-loop-helix transcription factor gene family in Arabidopsis thaliana.   DOI:  10.1105/tpc.151140 ;  PMID:  14600211
• JASMONATE-INSENSITIVE1 encodes a MYC transcription factor essential to discriminate between different jasmonate-regulated defense responses in Arabidopsis.   DOI:  10.1105/tpc.022319 ;  PMID:  15208388
• Microarray analysis of genes that respond to gamma-irradiation in Arabidopsis.   DOI:  10.1021/jf0486895 ;  PMID:  15713015
• Expression profiling reveals COI1 to be a key regulator of genes involved in and methyl jasmonate-induced secondary metabolism, defence, and hormone interactions.   DOI:  10.1007/s11103-005-7306-5 ;  PMID:  16021335
• Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana.   DOI:  10.1093/molbev/msq204 ;  PMID:  20736450
• The Arabidopsis bHLH transcription factors MYC3 and MYC4 are targets of JAZ repressors and act additively with MYC2 in the activation of jasmonate responses.   DOI:  10.1105/tpc.110.080788 ;  PMID:  21335373
• Characterization of JAZ-interacting bHLH transcription factors that regulate jasmonate responses in Arabidopsis.   DOI:  10.1093/jxb/erq408 ;  PMID:  21321051
• Analysis of IIId, IIIe and IVa group basic-helix-loop-helix proteins expressed in Arabidopsis root epidermis.   DOI:  10.1016/j.plantsci.2011.07.006 ;  PMID:  21889054
• The Arabidopsis JAZ2 promoter contains a G-Box and thymidine-rich module that are necessary and sufficient for jasmonate-dependent activation by MYC transcription factors and repression by JAZ proteins.   DOI:  10.1093/pcp/pcr178 ;  PMID:  22173100
• MYC2: the master in action.   DOI:  10.1093/mp/sss128 ;  PMID:  23142764
• Negative feedback control of jasmonate signaling by an alternative splice variant of JAZ10.   DOI:  10.1104/pp.113.218164 ;  PMID:  23632853
• Arabidopsis basic helix-loop-helix transcription factors MYC2, MYC3, and MYC4 regulate glucosinolate biosynthesis, insect performance, and feeding behavior.   DOI:  10.1105/tpc.113.115139 ;  PMID:  23943862
• Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.   DOI:  10.1186/1471-2229-13-229 ;  PMID:  24377444
• Repression of Jasmonate-Dependent Defenses by Shade Involves Differential Regulation of Protein Stability of MYC Transcription Factors and Their JAZ Repressors in Arabidopsis.   DOI:  10.1105/tpc.114.125047 ;  PMID:  24824488
• Male sterility in Arabidopsis induced by overexpression of a MYC5-SRDX chimeric repressor.   DOI:  10.1111/tpj.12776 ;  PMID:  25627909
• Change of a conserved amino acid in the MYC2 and MYC3 transcription factors leads to release of JAZ repression and increased activity.   DOI:  10.1111/nph.13398 ;  PMID:  25817565
• Regulation of Jasmonate-Mediated Stamen Development and Seed Production by a bHLH-MYB Complex in Arabidopsis.   DOI:  10.1105/tpc.15.00116 ;  PMID:  26002869
• Regulation of Jasmonate-Induced Leaf Senescence by Antagonism between bHLH Subgroup IIIe and IIId Factors in Arabidopsis.   DOI:  10.1105/tpc.15.00110 ;  PMID:  26071420
• Multilayered Organization of Jasmonate Signalling in the Regulation of Root Growth.   DOI:  10.1371/journal.pgen.1005300 ;  PMID:  26070206
• The RING E3 Ligase KEEP ON GOING Modulates JASMONATE ZIM-DOMAIN12 Stability.   DOI:  10.1104/pp.15.00479 ;  PMID:  26320228
• Novel JAZ co-operativity and unexpected JA dynamics underpin Arabidopsis defence responses to Pseudomonas syringae infection.   DOI:  10.1111/nph.13683 ;  PMID:  26428397
• JAZ7 negatively regulates dark-induced leaf senescence in Arabidopsis.   DOI:  10.1093/jxb/erv487 ;  PMID:  26547795
• New perspective of the bHLH-MYB complex in jasmonate-regulated plant fertility in arabidopsis.   DOI:  10.1080/15592324.2015.1135280 ;  PMID:  26829586
• Characterization of a JAZ7 activation-tagged Arabidopsis mutant with increased susceptibility to the fungal pathogen Fusarium oxysporum.   DOI:  10.1093/jxb/erw040 ;  PMID:  26896849
• Arabidopsis MYC Transcription Factors Are the Target of Hormonal Salicylic Acid/Jasmonic Acid Cross Talk in Response to Pieris brassicae Egg Extract.   DOI:  10.1104/pp.16.00031 ;  PMID:  26884488
• MYC2, MYC3, and MYC4 function redundantly in seed storage protein accumulation in Arabidopsis.   DOI:  10.1016/j.plaphy.2016.07.004 ;  PMID:  27415132
• JAZ2 controls stomata dynamics during bacterial invasion.   DOI:  10.1111/nph.14354 ;  PMID:  28005270
• Crystal Structure of Tetrameric Arabidopsis MYC2 Reveals the Mechanism of Enhanced Interaction with DNA.   DOI:  10.1016/j.celrep.2017.04.057 ;  PMID:  28514654
• The bHLH Transcription Factors MYC2, MYC3, and MYC4 Are Required for Jasmonate-Mediated Inhibition of Flowering in Arabidopsis.   DOI:  10.1016/j.molp.2017.08.007 ;  PMID:  28827172
• MYC5 is Involved in Jasmonate-Regulated Plant Growth, Leaf Senescence and Defense Responses.   DOI:  10.1093/pcp/pcx112 ;  PMID:  29017003
• Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis.   DOI:  10.1105/tpc.17.00805 ;  PMID:  29317470
• Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.   DOI:  10.1104/pp.17.00444 ;  PMID:  29496884
• Blue Light Regulates Secondary Cell Wall Thickening via MYC2/MYC4 Activation of the NST1-Directed Transcriptional Network in Arabidopsis.   DOI:  10.1105/tpc.18.00315 ;  PMID:  30242037
• Extracellular ATP Shapes a Defense-Related Transcriptome Both Independently and along with Other Defense Signaling Pathways.   DOI:  10.1104/pp.18.01301 ;  PMID:  30630869
• Regulation Mechanism of MYC Family Transcription Factors in Jasmonic Acid Signalling Pathway on Taxol Biosynthesis.   DOI:  10.3390/ijms20081843 ;  PMID:  31013972
• NAI2 and TSA1 Drive Differentiation of Constitutive and Inducible ER Body Formation in Brassicaceae.   DOI:  10.1093/pcp/pcz236 ;  PMID:  31879762
• MYC2, MYC3, and MYC4 function additively in wounding-induced jasmonic acid biosynthesis and catabolism.   DOI:  10.1111/jipb.12902 ;  PMID:  31876387
• Light promotes jasmonate biosynthesis to regulate photomorphogenesis in Arabidopsis.   DOI:  10.1007/s11427-019-1584-4 ;  PMID:  31974860
• MYCs and PIFs Act Independently in Arabidopsis Growth Regulation.   DOI:  10.1534/g3.120.401188 ;  PMID:  32220954
• Ring/U-Box Protein AtUSR1 Functions in Promoting Leaf Senescence Through JA Signaling Pathway in Arabidopsis.   DOI:  10.3389/fpls.2020.608589 ;  PMID:  33391323
• Abscisic acid-mediated induction of FLAVIN-CONTAINING MONOOXYGENASE 2 leads to reduced accumulation of methylthioalkyl glucosinolates in Arabidopsis thaliana.   DOI:  10.1016/j.plantsci.2020.110764 ;  PMID:  33487349
• Differential Contributions of MYCs to Insect Defense Reveals Flavonoids Alleviating Growth Inhibition Caused by Wounding in Arabidopsis.   DOI:  10.3389/fpls.2021.700555 ;  PMID:  34326858
• Effects of BrMYC2/3/4 on Plant Development, Glucosinolate Metabolism, and Sclerotinia sclerotiorum Resistance in Transgenic Arabidopsis thaliana.   DOI:  10.3389/fpls.2021.707054 ;  PMID:  34539701
• Jasmonic Acid-Dependent MYC Transcription Factors Bind to a Tandem G-Box Motif in the YUCCA8 and YUCCA9 Promoters to Regulate Biotic Stress Responses.   DOI:  10.3390/ijms22189768 ;  PMID:  34575927
• Multiple indole glucosinolates and myrosinases defend Arabidopsis against Tetranychus urticae herbivory.   DOI:  10.1093/plphys/kiab247 ;  PMID:  34618148
• A Phytochrome B-PIF4-MYC2/MYC4 module inhibits secondary cell wall thickening in response to shaded light.   DOI:  10.1016/j.xplc.2022.100416 ;  PMID:  35927944
• Long-lasting memory of jasmonic acid-dependent immunity requires DNA demethylation and ARGONAUTE1.   DOI:  10.1038/s41477-022-01313-9 ;  PMID:  36604579
• PHOSPHATE STARVATION RESPONSE1 (PHR1) interacts with JASMONATE ZIM-DOMAIN (JAZ) and MYC2 to modulate phosphate deficiency-induced jasmonate signaling in Arabidopsis.   DOI:  10.1093/plcell/koad057 ;  PMID:  36856677
• Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.   DOI:  10.1126/science.290.5499.2105 ;  PMID:  11118137
• The basic helix-loop-helix transcription factor family in plants: a genome-wide study of protein structure and functional diversity.   DOI:  10.1093/molbev/msg088 ;  PMID:  12679534

Sequence: