Gene Details:

• Gene ID: AT4G26090
• Gene Symbol: RPS2
• Gene Name: RESISTANT TO P. SYRINGAE 2
• Description: NB-ARC domain-containing disease resistance protein;(source:Araport11)
• TAIR Accession: locus:2005517
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT4G26090.1

Plant Ontology Annotations:

• PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
• PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
• PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
• PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
• PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
• PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
• PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
• PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
• PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
• PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
• PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)

Gene Ontology:

• GO:0042742  — acts upstream of or within — defense response to bacterium
• GO:0098542  — involved in — defense response to other organism
• GO:0016045  — acts upstream of or within — detection of bacterium
• GO:0005515  — enables — protein binding
• GO:0009626  — acts upstream of or within — plant-type hypersensitive response
• GO:0006952  — acts upstream of or within — defense response
• GO:0005886  — located in — plasma membrane
• GO:0043531  — enables — ADP binding

Germplasm Phenotype:

• CS6196  — susceptible to Pseudomonas syringae pv. tomato (Pst) strains expressing the avirulence gene avr Rpt2; only evident phenotypes are the appearance of disease symptoms and the lack of a visible hypersensitive response when the plants are inoculated with Pst (avr Rpt2).
• CS68740  — Susceptible to bacterial pathogen Pseudomonas syringae pv. tomato DC3000 (Pto DC3000) carrying virulence effector gene avrRpm1, avrB, or avrRpt2.
• CS68760  — Susceptible to pathogen Pto DC3000 carrying virulence effector gene avrRpm1or avrRpt2.
• CS68772  — Susceptible to pathogen Pto DC3000 carrying virulence effector gene avrRpm1or avrRpt2.
• CS68783  — No visible phenotype.
• CS68792  — No visible phenotype.
• CS68793  — No visible phenotype.
• CS72197  — Full loss-of-function for RPM1 against P. syringae type III effector protein AvrB, and partial loss-of-function for RPM1 against P. syringae type II effector protein AvrRpm1.
• CS72198  — Small, chlorotic plants under long day growth conditions. Gain-of-function for RPM1, up-regulated PR1.
• CS72200  — Suppressed callose accumulation upon flg22 treatment.
• CS72201  — Enhanced callose accumulation upon flg22 treatment. Weak enhanced disease resistance (EDR) phenotype against P. syringae virulence strain DC3000.
• CS72202  — Enhanced callose accumulation upon flg22 treatment. Weak enhanced disease resistance (EDR) phenotype against P. syringae virulence strain DC3000.
• CS72204  — Suppression of callose accumulation upon flg22 treatment. Weak enhanced disease susceptibility (EDS) phenotype against P. syringae virulence strain DC3000.
• CS72205  — Suppression of callose accumulation upon flg22 treatment. Weak enhanced disease susceptibility (EDS) phenotype against P. syringae virulence strain DC3000.

Function-related keywords:

• shoot axis apex ,  leaf lamina base ,  shoot system ,  vascular leaf ,  stamen ,  sepal ,  flower ,  cotyledon ,  petiole ,  leaf apex ,  collective leaf structure

Literature:

• Plant disease resistance genes encode members of an ancient and diverse protein family within the nucleotide-binding superfamily.   DOI:  10.1046/j.1365-313x.1999.t01-1-00606.x ;  PMID:  10571892
• Identification of three putative signal transduction genes involved in R gene-specified disease resistance in Arabidopsis.   DOI:  10.1093/genetics/152.1.401 ;  PMID:  10224270
• Different requirements for EDS1 and NDR1 by disease resistance genes define at least two R gene-mediated signaling pathways in Arabidopsis.   DOI:  10.1073/pnas.95.17.10306 ;  PMID:  9707643
• Glucocorticoid-inducible expression of a bacterial avirulence gene in transgenic Arabidopsis induces hypersensitive cell death.   DOI:  10.1046/j.1365-313x.1998.00106.x ;  PMID:  9628020
• Rapid construction of a transcription map for a cosmid contig of Arabidopsis thaliana genome using a novel cDNA selection method.   DOI:  10.1046/j.1365-313x.1997.12020481.x ;  PMID:  9301097
• Isolation of Arabidopsis genes that differentiate between resistance responses mediated by the RPS2 and RPM1 disease resistance genes.   DOI:  10.1105/tpc.8.2.241 ;  PMID:  8742710
• Arabidopsis NHO1 is required for general resistance against Pseudomonas bacteria.   DOI:  10.1105/tpc.13.2.437 ;  PMID:  11226196
• A high-performance, small-scale microarray for expression profiling of many samples in Arabidopsis-pathogen studies.   DOI:  10.1111/j.1365-313X.2006.02972.x ;  PMID:  17181774
• Constitutive activation of a CC-NB-LRR protein alters morphogenesis through the cytokinin pathway in Arabidopsis.   DOI:  10.1111/j.1365-313X.2008.03466.x ;  PMID:  18315541
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• The Pseudomonas syringae type III effector AvrRpm1 induces significant defenses by activating the Arabidopsis nucleotide-binding leucine-rich repeat protein RPS2.   DOI:  10.1111/j.1365-313X.2008.03716.x ;  PMID:  18980653
• Resistance to the Pseudomonas syringae effector HopA1 is governed by the TIR-NBS-LRR protein RPS6 and is enhanced by mutations in SRFR1.   DOI:  10.1104/pp.109.139238 ;  PMID:  19525323
• A pathogen-inducible endogenous siRNA in plant immunity.   DOI:  10.1073/pnas.0608258103 ;  PMID:  17071740
• Identification of an Arabidopsis Nodulin-related protein in heat stress.   DOI:  10.1007/s10059-010-0005-3 ;  PMID:  20016941
• Arabidopsis NDR1 is an integrin-like protein with a role in fluid loss and plasma membrane-cell wall adhesion.   DOI:  10.1104/pp.110.169656 ;  PMID:  21398259
• Physical association of Arabidopsis hypersensitive induced reaction proteins (HIRs) with the immune receptor RPS2.   DOI:  10.1074/jbc.M110.211615 ;  PMID:  21757708
• N-terminal motifs in some plant disease resistance proteins function in membrane attachment and contribute to disease resistance.   DOI:  10.1094/MPMI-11-10-0272 ;  PMID:  22046960
• Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.   DOI:  10.1186/1471-2229-13-229 ;  PMID:  24377444
• The Arabidopsis immune adaptor SRFR1 interacts with TCP transcription factors that redundantly contribute to effector-triggered immunity.   DOI:  10.1111/tpj.12527 ;  PMID:  24689742
• HSP90s are required for NLR immune receptor accumulation in Arabidopsis.   DOI:  10.1111/tpj.12573 ;  PMID:  24889324
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• Plant TRAF Proteins Regulate NLR Immune Receptor Turnover.   DOI:  10.1016/j.chom.2016.01.005 ;  PMID:  26867179
• Comparative Genomics of Non-TNL Disease Resistance Genes from Six Plant Species.   DOI:  10.3390/genes8100249 ;  PMID:  28973974
• Leaf stage-associated resistance is correlated with phytohormones in a pathosystem-dependent manner.   DOI:  10.1111/jipb.12661 ;  PMID:  29704401
• The Polycomb-Group Repressor MEDEA Attenuates Pathogen Defense.   DOI:  10.1104/pp.17.01579 ;  PMID:  29954867
• Quantitative phosphoproteomic analysis reveals common regulatory mechanisms and PAMP-triggered immunity in plants.   DOI:  10.1111/nph.15523 ;  PMID:  30300945
• Pathogen-Associated Molecular Pattern-Triggered Immunity Involves Proteolytic Degradation of Core Nonsense-Mediated mRNA Decay Factors During the Early Defense Response.   DOI:  10.1105/tpc.19.00631 ;  PMID:  32086363
• MEDEA-interacting protein LONG-CHAIN BASE KINASE 1 promotes pattern-triggered immunity in Arabidopsis thaliana.   DOI:  10.1007/s11103-020-00982-4 ;  PMID:  32100164
• Genetic requirements for infection-specific responses in conferring disease resistance in Arabidopsis.   DOI:  10.3389/fpls.2022.1068438 ;  PMID:  36523630
• Homeostasis of Arabidopsis R protein RPS2 is negatively regulated by the RING-type E3 ligase MUSE16.   DOI:  10.1093/jxb/erad026 ;  PMID:  36655859

Sequence: