Gene Details:

  • Gene ID: AT4G29130
  • Gene Symbol: ATHXK1, GIN2, HXK1
  • Gene Name: ARABIDOPSIS THALIANA HEXOKINASE 1, GLUCOSE INSENSITIVE 2, hexokinase 1
  • Description: hexokinase 1;(source:Araport11)
  • TAIR Accession: locus:2119931
  • Genome: Araport11_genome_release
  • Species: Arabidopsis thaliana

Transcripts:

Plant Ontology Annotations:

  • PO:0000037  — shoot axis apex — ápice del epiblasto (epiblastema) (Spanish, exact), シュート頂、茎頂 (Japanese, exact)
  • PO:0008019  — leaf lamina base — base de la lámina de la hoja (Spanish, exact), 葉身基部 (Japanese, exact)
  • PO:0009006  — shoot system — sistema de epiblasto (epiblastema) (Spanish, exact), シュート系、苗条系 (Japanese, exact), Poaceae crown (related), shoot (related), thalli (related), thallus (related), tree crown (narrow)
  • PO:0009009  — plant embryo — embrión (Spanish, exact), 植物胚 (Japanese, exact), germ (related), embryo (broad)
  • PO:0009025  — vascular leaf — foliage leaf (exact), hoja vascular (Spanish, exact), leaf, vascular (exact), vascular leaves (exact, plural), 維管束のある葉, または維管束植物の葉 (Japanese, exact), crozier (related), macrophyll (related), megaphyll (related), ascidia (narrow), ascidium (narrow), fiddlehead (narrow), frond (narrow), needle-like leaf (narrow), pitcher (narrow), pitcher blade (narrow), pitcher-blade (narrow), scale-like leaf (narrow), sterile frond (narrow), trophophyll (narrow)
  • PO:0009029  — stamen — estambre (Spanish, exact), 雄蕊 (Japanese, exact), Poaceae stamen (narrow), Zea stamen (narrow)
  • PO:0009031  — sepal — sépalo (Spanish, exact), がく片 (Japanese, exact)
  • PO:0009046  — flower — flor (Spanish, exact), 花 (Japanese, exact), floret (related), Asteraceae floret (narrow), basal flower (narrow), double flower (narrow), hermaphrodite flower (narrow), monoclinous flower (narrow), perfect flower (narrow)
  • PO:0009052  — inflorescence flower pedicel — 小花柄 (Japanese, related), pedicelo (Spanish, broad)
  • PO:0020030  — cotyledon — cotiledón (Spanish, exact), seed leaf (exact), 子葉 (Japanese, exact)
  • PO:0020038  — petiole — pecíolo (Spanish, exact), 葉柄 (Japanese, exact)
  • PO:0020100  — hypocotyl — hipocótile (Spanish, exact), 胚軸 (Japanese, exact)
  • PO:0020137  — leaf apex — ápice de la hoja (Spanish, exact), 葉先 (Japanese, exact), leaf lamina apex (narrow), phyllid apex (narrow)
  • PO:0025022  — collective leaf structure — estructura colectiva de hoja (Spanish, exact), leaf series (exact), 葉が集まった構造 (Japanese, exact), leaf whorl (narrow), rosette (narrow), cycle (broad), verticil (broad)
  • PO:0025281  — pollen — polen (Spanish, exact), pollen grain (exact), 花粉 (Japanese, exact)

Gene Ontology:

  • GO:0005739  — located in — mitochondrion
  • GO:0006096  — involved in — glycolytic process
  • GO:0010255  — acts upstream of or within — glucose mediated signaling pathway
  • GO:0090332  — acts upstream of or within — stomatal closure
  • GO:0005515  — enables — protein binding
  • GO:0000325  — located in — plant-type vacuole
  • GO:0051156  — involved in — glucose 6-phosphate metabolic process
  • GO:2000032  — acts upstream of or within — regulation of secondary shoot formation
  • GO:0008270  — enables — zinc ion binding
  • GO:0005536  — enables — glucose binding
  • GO:0010182  — acts upstream of or within — sugar mediated signaling pathway
  • GO:0004340  — enables — glucokinase activity
  • GO:0005829  — is active in — cytosol
  • GO:0006006  — involved in — glucose metabolic process
  • GO:0004396  — enables — hexokinase activity
  • GO:0019320  — acts upstream of or within — hexose catabolic process
  • GO:0008865  — enables — fructokinase activity
  • GO:0012501  — acts upstream of or within — programmed cell death
  • GO:0005739  — is active in — mitochondrion
  • GO:0046835  — involved in — carbohydrate phosphorylation
  • GO:0005634  — located in — nucleus
  • GO:0010148  — acts upstream of or within — transpiration
  • GO:0001678  — involved in — intracellular glucose homeostasis

Germplasm Phenotype:

  • CS6383  — Addition of cytokinin promotes extensive shoot induction in mutant but not in WT calli.
  • CS6383  — At the flowering stage, the mutant has a smaller root system, tiny leaves with delayed senescence, shorter petioles and inflorescences, and a reduced number of flowers and siliques. Trichomes are normal and flower size and shape, and produced fertile seeds (albeit in reduced number).
  • CS6383  — Defect in elongation of hypocotyl, roots, and cotyledons in dim light (15 μmol/m2/s).
  • CS6383  — Delayed leaf senescence.
  • CS6383  — Glucose insensitivity; develop green cotyledons and leaves on 6% glucose MS medium under 50uE light intensity at 23-28C; develop small rosettes (dark-green leaves with short petiols) and small plants when grown on soil under 250 uE light intensity at 23-25C; nitrate antagonizes the sugar phenotypes
  • CS6383  — Insensitive to high-glucose repression of chlorophyll accumulation in seedlings.
  • CS6383  — Insensitive to high-glucose repression of cotyledon expansion, chlorophyll accumulation, true-leaf development and root elongation. The response is specific to glucose but not to osmotic changes.
  • CS6383  — Leaves of the mutant have about one-half the glucose phosphorylation capacity of wild-type leaves when grown under low or high light conditions.
  • CS6383  — Leaves remain small and dark green with little cell expansion under high light conditions, although the same number of leaves appeared at the same time as in the wild type.
  • CS69135  — Reduced growth in roots, leaf and stem length, rosette size and inflorescence.
  • CS69136  — Reduced growth in roots, leaf length, and rosette size. Intermediate growth phenotype between hxk1-3 and rgs1-2 single mutants.
  • CS69140  — Reduced growth in roots, leaf and stem length, rosette size and inflorescence. YFP expression localized to the plasma membrane without glucose, and endocytosed upon D-glucose treatment.
  • CS69141  — Reduced growth in roots, leaf and stem length, rosette size and inflorescence. YFP expression localized to the plasma membrane without glucose, and endocytosed upon D-glucose treatment.
  • CS69142  — Reduced growth in roots, leaf and stem length, rosette size and inflorescence. YFP expression localized to the plasma membrane without glucose, and endocytosed upon D-glucose treatment.
  • CS69153  — Reduced growth in roots, leaf and stem length, rosette size and inflorescence.
  • SALK_070739  — Mutants do not display glucose mediated pollen tube growth inhibition.
  • gin2-2  — Addition of cytokinin promotes extensive shoot induction in mutant but not in WT calli.
  • gin2-2  — Insensitive to high-glucose repression of chlorophyll accumulation in seedlings.
  • siz1-2 hxk1-1  — Decreased rosette diameter, decreased percentage of seed germination (more than either single mutant.)

Literature:

Sequence:

cDNA Sequence
  • >AT4G29130.1 AAAACCGAAATTAGACAAAAGGTTAATTTCGTCATTTCAACAGATTCTATTACCACTTCTTGTTTTGTTTTTCCATACTTTACGGACAAGAACGAGAGAAGCTCTCGCTTACGTGGTTTCTACACTGTTTTTGACGAACCCACCAAGCTCGAGTAGATCGGTATTAGATCCATCTTAGGTTTCTCTAATTTCTCTCAATTCACTCCAAAATTTTGATTATTTCTTCTTTCTGGCTTGTCAATTTTAGTCATTTGTAATCCTTGCTTTTGCGATCGGAATCGTAAAAATCCGATCTTTCTTTTAGATTCGTTTTGTTTTTGATTCCAAATCGGAAAAATGGGTAAAGTAGCTGTTGGAGCGACTGTTGTTTGCACGGCGGCGGTTTGTGCGGTGGCTGTTTTGGTTGTTCGACGACGGATGCAGAGCTCAGGGAAGTGGGGACGTGTTTTGGCTATCCTCAAGGCCTTTGAAGAGGATTGTGCGACTCCGATCTCGAAACTGAGACAAGTGGCTGATGCTATGACCGTTGAGATGCATGCTGGTCTTGCATCCGACGGTGGTAGCAAACTCAAGATGCTTATCAGCTACGTTGATAATCTTCCTTCCGGGGATGAAAAGGGTCTCTTTTATGCATTGGACCTAGGGGGGACAAACTTCCGTGTCATGCGTGTGCTTCTTGGCGGGAAGCAAGAGCGTGTTGTTAAACAAGAATTCGAAGAAGTTTCGATTCCTCCTCATTTGATGACTGGTGGTTCAGATGAGTTGTTCAATTTTATAGCTGAAGCTCTTGCGAAGTTTGTCGCTACAGAATGCGAAGACTTTCATCTTCCAGAAGGTAGACAGAGGGAATTAGGTTTCACTTTCTCGTTTCCTGTTAAGCAGACTTCTCTGTCCTCTGGTAGTCTCATCAAATGGACAAAAGGCTTTTCCATCGAAGAAGCAGTTGGACAAGATGTTGTTGGAGCACTTAATAAGGCTCTGGAAAGAGTTGGTCTTGACATGCGAATCGCAGCACTTGTTAATGATACCGTTGGAACACTAGCCGGTGGTAGATACTATAACCCGGATGTTGTTGCTGCTGTTATTTTAGGCACTGGGACAAACGCAGCCTATGTTGAGCGTGCAACCGCGATCCCTAAATGGCATGGTCTGCTTCCAAAATCAGGAGAAATGGTTATAAACATGGAATGGGGAAACTTCAGGTCATCACATCTTCCATTAACCGAGTTTGATCACACGCTGGATTTCGAGAGTCTGAATCCAGGCGAACAGATTCTTGAGAAAATCATTTCCGGTATGTACTTGGGAGAGATTTTGCGAAGAGTTCTTCTAAAGATGGCTGAAGATGCTGCTTTCTTTGGCGATACAGTCCCATCTAAGCTGAGAATACCATTCATCATTAGGACTCCTCACATGTCGGCTATGCACAACGACACTTCTCCAGACTTGAAGATTGTTGGGAGCAAGATTAAGGATATATTGGAGGTCCCTACAACTTCTCTGAAAATGAGAAAAGTTGTGATCAGTCTCTGCAACATCATAGCAACCCGAGGAGCTCGTCTCTCTGCTGCTGGAATCTATGGTATTCTGAAGAAACTGGGAAGAGATACTACTAAAGACGAGGAGGTGCAGAAATCGGTTATAGCCATGGATGGTGGATTGTTTGAGCATTACACTCAGTTTAGTGAGTGTATGGAGAGCTCACTAAAAGAGTTGCTTGGAGATGAAGCTTCAGGAAGCGTTGAAGTCACTCACTCCAATGATGGATCAGGCATTGGAGCTGCGCTTCTTGCTGCTTCTCACTCTCTCTACCTTGAAGACTCTTAAAACCTACCCAAAGAGCGCCATTTTTCGGTAATTTACTGAAAGCTTTTCGCTATCAGAAAACGCCTAAGCCAAGTTCTAAGGCGTCATAAAAGAAAGCATTCCATGTTTTTACTCTTCCCCAAGACTTTCTTTGTAGCAAATAAGTTTCCTTGGGAGAAATATTTGTTTTCATGTTCTTCAAAAATAAAAGACTCAGTTCTTCAGATTCTGGGATTTTATTATAACCAGATATGTTGTAAAAACTACAAATTCAAAGCTCACTTCACTGGAGTTCTGAGTATATAAAGATTTCATTTTTCCT
CDS Sequence
Protein Sequence