Gene Details:

• Gene ID: AT5G13320
• Gene Symbol: AtGH3.12, GDG1, GH3.12, PBS3, WIN3
• Gene Name: GH3-LIKE DEFENSE GENE 1, GRETCHEN HAGEN 3.12, AVRPPHB SUSCEPTIBLE 3, HOPW1-1-INTERACTING 3
• Description: Auxin-responsive GH3 family protein;(source:Araport11)
• TAIR Accession: locus:6530584248
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G13320.1     AT5G13320.2     AT5G13320.3

Gene Ontology:

• GO:0010112  — involved in — regulation of systemic acquired resistance
• GO:0034052  — involved in — positive regulation of plant-type hypersensitive response
• GO:0005634  — located in — nucleus
• GO:0005737  — is active in — cytoplasm
• GO:0016881  — enables — acid-amino acid ligase activity
• GO:0042742  — acts upstream of or within — defense response to bacterium
• GO:0005515  — enables — protein binding

Germplasm Phenotype:

• CS67960  — Fail to accumulate salicylic acid in response to both virulent and avirulent pathogen
• CS67960  — Increased susceptibility to virulent Pseudomonas syringae pv. tomato strains and to P. syringae DC3000 carrying avrRpt2, avrB, avrRps4 or avrPphB resulting in chlorosis and water-soaked lesions after infection.
• CS67960  — Susceptible to specific strains of P. syringae
• gh3.7 gh3.12  — Increased susceptibility to P. syringae DC3000.

Literature:

• Identification of three putative signal transduction genes involved in R gene-specified disease resistance in Arabidopsis.   DOI:  10.1093/genetics/152.1.401 ;  PMID:  10224270
• Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components.   DOI:  10.1046/j.0960-7412.2001.01229.x ;  PMID:  11846877
• The atypical resistance gene, RPW8, recruits components of basal defence for powdery mildew resistance in Arabidopsis.   DOI:  10.1111/j.1365-313X.2005.02356.x ;  PMID:  15773856
• Genetic analysis of developmentally regulated resistance to downy mildew (Hyaloperonospora parasitica) in Arabidopsis thaliana.   DOI:  10.1094/MPMI-18-1226 ;  PMID:  16353557
• Arabidopsis GH3-LIKE DEFENSE GENE 1 is required for accumulation of salicylic acid, activation of defense responses and resistance to Pseudomonas syringae.   DOI:  10.1111/j.1365-313X.2007.03130.x ;  PMID:  17521413
• Arabidopsis proteins important for modulating defense responses to Pseudomonas syringae that secrete HopW1-1.   DOI:  10.1111/j.1365-313X.2008.03439.x ;  PMID:  18266921
• Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection.   DOI:  10.1104/pp.108.121038 ;  PMID:  18650403
• The genetic network controlling the Arabidopsis transcriptional response to Pseudomonas syringae pv. maculicola: roles of major regulators and the phytotoxin coronatine.   DOI:  10.1094/MPMI-21-11-1408 ;  PMID:  18842091
• Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana.   DOI:  10.1093/molbev/msq204 ;  PMID:  20736450
• The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses during hypoxia in Arabidopsis.   DOI:  10.1104/pp.111.172486 ;  PMID:  21398256
• WRKY transcription factors involved in activation of SA biosynthesis genes.   DOI:  10.1186/1471-2229-11-89 ;  PMID:  21595875
• Multiple roles of WIN3 in regulating disease resistance, cell death, and flowering time in Arabidopsis.   DOI:  10.1104/pp.111.176776 ;  PMID:  21543726
• Structural basis for prereceptor modulation of plant hormones by GH3 proteins.   DOI:  10.1126/science.1221863 ;  PMID:  22628555
• Isochorismate-derived biosynthesis of the plant stress hormone salicylic acid.   DOI:  10.1126/science.aaw1720 ;  PMID:  31371615
• Brassicaceae-specific Gretchen Hagen 3 acyl acid amido synthetases conjugate amino acids to chorismate, a precursor of aromatic amino acids and salicylic acid.   DOI:  10.1074/jbc.RA119.009949 ;  PMID:  31575658
• WRKY55 transcription factor positively regulates leaf senescence and the defense response by modulating the transcription of genes implicated in the biosynthesis of reactive oxygen species and salicylic acid in Arabidopsis.   DOI:  10.1242/dev.189647 ;  PMID:  32680933
• PBS3: a versatile player in and beyond salicylic acid biosynthesis in Arabidopsis.   DOI:  10.1111/nph.18558 ;  PMID:  36263689
• The Arabidopsis thaliana trehalose-6-phosphate phosphatase gene AtTPPI regulates primary root growth and lateral root elongation.   DOI:  10.3389/fpls.2022.1088278 ;  PMID:  36714693
• The GH3 acyl adenylase family member PBS3 regulates salicylic acid-dependent defense responses in Arabidopsis.   DOI:  10.1104/pp.107.097691 ;  PMID:  17468220

Sequence: