Gene Details:

• Gene ID: AT5G13530
• Gene Symbol: KEG
• Gene Name: KEEP ON GOING
• Description: protein kinases;(source:Araport11)
• TAIR Accession: locus:2185061
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G13530.1     AT5G13530.2

Plant Ontology Annotations:

• PO:0009005  — root — raíz (Spanish, exact), radices (exact, plural), radix (exact), 根 (Japanese, exact), aerial root (narrow), climbing root (narrow)

Gene Ontology:

• GO:0009738  — acts upstream of or within — abscisic acid-activated signaling pathway
• GO:0004842  — enables — ubiquitin-protein transferase activity
• GO:0032940  — acts upstream of or within — secretion by cell
• GO:0016197  — acts upstream of or within — endosomal transport
• GO:0006468  — involved in — protein phosphorylation
• GO:0004672  — enables — protein kinase activity
• GO:0005524  — enables — ATP binding
• GO:0005622  — located in — intracellular anatomical structure
• GO:0005515  — enables — protein binding
• GO:0009738  — involved in — abscisic acid-activated signaling pathway
• GO:0009788  — acts upstream of or within — negative regulation of abscisic acid-activated signaling pathway
• GO:0004674  — enables — protein serine/threonine kinase activity
• GO:0005769  — is active in — early endosome
• GO:0005769  — located in — early endosome
• GO:0045324  — involved in — late endosome to vacuole transport
• GO:0005802  — located in — trans-Golgi network
• GO:0009737  — acts upstream of or within — response to abscisic acid
• GO:0009788  — involved in — negative regulation of abscisic acid-activated signaling pathway
• GO:0045324  — acts upstream of or within — late endosome to vacuole transport
• GO:0043621  — enables — protein self-association
• GO:0048589  — acts upstream of or within — developmental growth
• GO:0005737  — located in — cytoplasm
• GO:0006952  — acts upstream of or within — defense response
• GO:0006952  — involved in — defense response
• GO:0005802  — is active in — trans-Golgi network

Germplasm Phenotype:

• CS67951  — Decreased sensitivity to glucose.
• CS67952  — Decreased sensitivity to glucose. Suppression of all known edr1 phenotypes such as enhanced disease resistance to powdery mildew, enhanced ethylene-induced senescence, drought-induced growth inhibition, and ABA hypersensitivity.
• keg-4  — Enhanced susceptibility to powdery mildew; MKK4 and MKK5 protein levels are reduced.

Function-related keywords:

• root

Literature:

• An Arabidopsis mutant with enhanced resistance to powdery mildew.   DOI:  10.1105/tpc.10.6.947 ;  PMID:  9634583
• Evaluation and classification of RING-finger domains encoded by the Arabidopsis genome.   DOI:  10.1186/gb-2002-3-4-research0016 ;  PMID:  11983057
• Functional analysis of the RING-type ubiquitin ligase family of Arabidopsis.   DOI:  10.1104/pp.104.052423 ;  PMID:  15644464
• KEEP ON GOING, a RING E3 ligase essential for Arabidopsis growth and development, is involved in abscisic acid signaling.   DOI:  10.1105/tpc.106.046532 ;  PMID:  17194765
• Powdery mildew resistance conferred by loss of the ENHANCED DISEASE RESISTANCE1 protein kinase is suppressed by a missense mutation in KEEP ON GOING, a regulator of abscisic acid signaling.   DOI:  10.1104/pp.108.127605 ;  PMID:  18815384
• Abscisic acid increases Arabidopsis ABI5 transcription factor levels by promoting KEG E3 ligase self-ubiquitination and proteasomal degradation.   DOI:  10.1105/tpc.110.076075 ;  PMID:  20682837
• The KEEP ON GOING protein of Arabidopsis recruits the ENHANCED DISEASE RESISTANCE1 protein to trans-Golgi network/early endosome vesicles.   DOI:  10.1104/pp.110.171785 ;  PMID:  21343429
• Cytoplasmic degradation of the Arabidopsis transcription factor abscisic acid insensitive 5 is mediated by the RING-type E3 ligase KEEP ON GOING.   DOI:  10.1074/jbc.M113.465369 ;  PMID:  23720747
• Arabidopsis CIPK26 interacts with KEG, components of the ABA signalling network and is degraded by the ubiquitin-proteasome system.   DOI:  10.1093/jxb/ert123 ;  PMID:  23658427
• ABA and the ubiquitin E3 ligase KEEP ON GOING affect proteolysis of the Arabidopsis thaliana transcription factors ABF1 and ABF3.   DOI:  10.1111/tpj.12259 ;  PMID:  23742014
• Regulation of ABI5 turnover by reversible post-translational modifications.   DOI:  10.4161/psb.27577 ;  PMID:  24398698
• The RING E3 Ligase KEEP ON GOING Modulates JASMONATE ZIM-DOMAIN12 Stability.   DOI:  10.1104/pp.15.00479 ;  PMID:  26320228
• The Kinase Activity of Calcineurin B-like Interacting Protein Kinase 26 (CIPK26) Influences Its Own Stability and that of the ABA-regulated Ubiquitin Ligase, Keep on Going (KEG).   DOI:  10.3389/fpls.2017.00502 ;  PMID:  28443108
• Arabidopsis E3 ligase KEG associates with and ubiquitinates MKK4 and MKK5 to regulate plant immunity.   DOI:  10.1111/jipb.13007 ;  PMID:  32877006
• Factors that affect protein abundance of a positive regulator of abscisic acid signalling, the basic leucine zipper transcription factor ABRE-binding factor 2 (ABF2).   DOI:  10.1002/pld3.330 ;  PMID:  34222769
• ABI5 binding protein2 inhibits ABA responses during germination without ABA-INSENSITIVE5 degradation.   DOI:  10.1093/plphys/kiac096 ;  PMID:  35258597
• Repertoire of plant RING E3 ubiquitin ligases revisited: New groups counting gene families and single genes.   DOI:  10.1371/journal.pone.0203442 ;  PMID:  30169501

Sequence: