Gene Details:

• Gene ID: AT5G28030
• Gene Symbol: DES1
• Gene Name: L-cysteine desulfhydrase 1
• Description: L-cysteine desulfhydrase 1;(source:Araport11)
• TAIR Accession: locus:2143754
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G28030.1     AT5G28030.2     AT5G28030.5     AT5G28030.4     AT5G28030.3

Gene Ontology:

• GO:0006979  — acts upstream of or within — response to oxidative stress
• GO:0080146  — enables — L-cysteine desulfhydrase activity
• GO:0044540  — enables — L-cystine L-cysteine-lyase (deaminating)
• GO:0009507  — located in — chloroplast
• GO:0006535  — involved in — cysteine biosynthetic process from serine
• GO:0005737  — is active in — cytoplasm
• GO:1990170  — acts upstream of or within — stress response to cadmium ion
• GO:0030170  — enables — pyridoxal phosphate binding
• GO:0005737  — located in — cytoplasm
• GO:0004124  — enables — cysteine synthase activity
• GO:0004123  — enables — cystathionine gamma-lyase activity
• GO:0080145  — involved in — intracellular cysteine homeostasis
• GO:0080145  — acts upstream of or within — intracellular cysteine homeostasis

Germplasm Phenotype:

• CS868869  — Early flowering.
• CS868869  — Enhanced antioxidant defenses and tolerance to conditions that promote oxidative stress.

Literature:

• Overexpression of AtCpNifS enhances selenium tolerance and accumulation in Arabidopsis.   DOI:  10.1104/pp.105.068684 ;  PMID:  16244144
• Synthesis of the sulfur amino acids: cysteine and methionine.   DOI:  10.1007/s11120-005-8810-9 ;  PMID:  16307301
• Arabidopsis transcriptome changes in response to phloem-feeding silverleaf whitefly nymphs. Similarities and distinctions in responses to aphids.   DOI:  10.1104/pp.106.090662 ;  PMID:  17189325
• Physiological roles of the beta-substituted alanine synthase gene family in Arabidopsis.   DOI:  10.1104/pp.107.106831 ;  PMID:  18024555
• Analysis of the Arabidopsis O-acetylserine(thiol)lyase gene family demonstrates compartment-specific differences in the regulation of cysteine synthesis.   DOI:  10.1105/tpc.107.056747 ;  PMID:  18223034
• Transcription factors relevant to auxin signalling coordinate broad-spectrum metabolic shifts including sulphur metabolism.   DOI:  10.1093/jxb/ern144 ;  PMID:  18596113
• Functional compensation of primary and secondary metabolites by duplicate genes in Arabidopsis thaliana.   DOI:  10.1093/molbev/msq204 ;  PMID:  20736450
• Cysteine homeostasis plays an essential role in plant immunity.   DOI:  10.1111/j.1469-8137.2011.03889.x ;  PMID:  21988475
• Hydrogen sulfide generated by L-cysteine desulfhydrase acts upstream of nitric oxide to modulate abscisic acid-dependent stomatal closure.   DOI:  10.1104/pp.114.245373 ;  PMID:  25266633
• The role of compartment-specific cysteine synthesis for sulfur homeostasis during H2S exposure in Arabidopsis.   DOI:  10.1093/pcp/pcu166 ;  PMID:  25416292
• Hydrogen Sulfide Regulates the Cytosolic/Nuclear Partitioning of Glyceraldehyde-3-Phosphate Dehydrogenase by Enhancing its Nuclear Localization.   DOI:  10.1093/pcp/pcx056 ;  PMID:  28444344
• Hydrogen Sulfide Increases Production of NADPH Oxidase-Dependent Hydrogen Peroxide and Phospholipase D-Derived Phosphatidic Acid in Guard Cell Signaling.   DOI:  10.1104/pp.17.01636 ;  PMID:  29438048
• Hydrogen Sulfide Regulates Energy Production to Delay Leaf Senescence Induced by Drought Stress in Arabidopsis.   DOI:  10.3389/fpls.2018.01722 ;  PMID:  30532763
• The coordination of guard-cell autonomous ABA synthesis and DES1 function in situ regulates plant water deficit responses.   DOI:  10.1016/j.jare.2020.07.013 ;  PMID:  33318877
• Hydrogen sulfide-linked persulfidation of ABI4 controls ABA responses through the transactivation of MAPKKK18 in Arabidopsis.   DOI:  10.1016/j.molp.2021.03.007 ;  PMID:  33689930
• Hydrogen sulfide reduces cell death through regulating autophagy during submergence in Arabidopsis.   DOI:  10.1007/s00299-022-02872-z ;  PMID:  35507055

Sequence: