Gene Details:

• Gene ID: AT5G42800
• Gene Symbol: DFR, M318, TT3
• Gene Name: dihydroflavonol 4-reductase
• Description: dihydroflavonol 4-reductase;(source:Araport11)
• TAIR Accession: locus:2165427
• Genome: Araport11_genome_release
• Species: Arabidopsis thaliana

Transcripts:

• AT5G42800.1

Gene Ontology:

• GO:0009718  — acts upstream of or within — anthocyanin-containing compound biosynthetic process
• GO:0009718  — involved in — anthocyanin-containing compound biosynthetic process
• GO:0045552  — enables — dihydrokaempferol 4-reductase activity
• GO:0047890  — enables — flavanone 4-reductase activity
• GO:0042406  — located in — extrinsic component of endoplasmic reticulum membrane
• GO:0005515  — enables — protein binding

Literature:

• The BANYULS gene encodes a DFR-like protein and is a marker of early seed coat development.   DOI:  10.1046/j.1365-313x.1999.00529.x ;  PMID:  10504561
• Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations.   DOI:  10.1105/tpc.4.3.333 ;  PMID:  1354004
• The TT8 gene encodes a basic helix-loop-helix domain protein required for expression of DFR and BAN genes in Arabidopsis siliques.   DOI:  10.1105/tpc.12.10.1863 ;  PMID:  11041882
• Regulation of anthocyanin biosynthesis in UV-A-irradiated cell cultures of carrot and in organs of intact carrot plants.   DOI:  10.1016/s0168-9452(01)00408-3 ;  PMID:  11448762
• Cloning and molecular analysis of structural genes involved in flavonoid and stilbene biosynthesis in grape (Vitis vinifera L.).   DOI:  10.1007/BF00029856 ;  PMID:  8193299
• Molecular cloning and characterization of Rosa hybrida dihydroflavonol 4-reductase gene.   DOI:  10.1093/oxfordjournals.pcp.a078844 ;  PMID:  8528604
• Levels of active oxygen species are controlled by ascorbic acid and anthocyanin in Arabidopsis.   DOI:  10.1021/jf026179+ ;  PMID:  12720382
• Sucrose-specific induction of the anthocyanin biosynthetic pathway in Arabidopsis.   DOI:  10.1104/pp.105.072579 ;  PMID:  16384906
• MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis.   DOI:  10.1073/pnas.0509463102 ;  PMID:  16387852
• Over-expression of a flower-specific transcription factor gene AtMYB24 causes aberrant anther development.   DOI:  10.1007/s00299-006-0229-z ;  PMID:  16972096
• BEN1, a gene encoding a dihydroflavonol 4-reductase (DFR)-like protein, regulates the levels of brassinosteroids in Arabidopsis thaliana.   DOI:  10.1111/j.1365-313X.2007.03129.x ;  PMID:  17521414
• AtMYBL2, a protein with a single MYB domain, acts as a negative regulator of anthocyanin biosynthesis in Arabidopsis.   DOI:  10.1111/j.1365-313X.2008.03565.x ;  PMID:  18532977
• Architectural phenotypes in the transparent testa mutants of Arabidopsis thaliana.   DOI:  10.1093/jxb/ern323 ;  PMID:  19129166
• Transparent Testa Glabra 1 (TTG1) and TTG1-like genes in Matthiola incana R. Br. and related Brassicaceae and mutation in the WD-40 motif.   DOI:  10.1111/j.1438-8677.2008.00099.x ;  PMID:  19228327
• The endogenous GL3, but not EGL3, gene is necessary for anthocyanin accumulation as induced by nitrogen depletion in Arabidopsis rosette stage leaves.   DOI:  10.1007/s00425-009-0978-3 ;  PMID:  19621239
• Molecular mechanism for jasmonate-induction of anthocyanin accumulation in Arabidopsis.   DOI:  10.1093/jxb/erp223 ;  PMID:  19596700
• Features of anthocyanin biosynthesis in pap1-D and wild-type Arabidopsis thaliana plants grown in different light intensity and culture media conditions.   DOI:  10.1007/s00425-010-1142-9 ;  PMID:  20309578
• Auxin and ethylene induce flavonol accumulation through distinct transcriptional networks.   DOI:  10.1104/pp.111.172502 ;  PMID:  21427279
• Negative regulation of anthocyanin biosynthesis in Arabidopsis by a miR156-targeted SPL transcription factor.   DOI:  10.1105/tpc.111.084525 ;  PMID:  21487097
• Brassinosteroid enhances jasmonate-induced anthocyanin accumulation in Arabidopsis seedlings.   DOI:  10.1111/j.1744-7909.2011.01042.x ;  PMID:  21545406
• Characterization of the regulatory network of BoMYB2 in controlling anthocyanin biosynthesis in purple cauliflower.   DOI:  10.1007/s00425-012-1665-3 ;  PMID:  22644767
• Regulation of anthocyanin biosynthesis in Arabidopsis thaliana red pap1-D cells metabolically programmed by auxins.   DOI:  10.1007/s00425-013-2011-0 ;  PMID:  24370633
• Complexity and robustness of the flavonoid transcriptional regulatory network revealed by comprehensive analyses of MYB-bHLH-WDR complexes and their targets in Arabidopsis seed.   DOI:  10.1111/nph.12620 ;  PMID:  24299194
• A R2R3-MYB transcription factor, GmMYB12B2, affects the expression levels of flavonoid biosynthesis genes encoding key enzymes in transgenic Arabidopsis plants.   DOI:  10.1016/j.gene.2013.09.015 ;  PMID:  24060295
• The miR156-SPL9-DFR pathway coordinates the relationship between development and abiotic stress tolerance in plants.   DOI:  10.1111/tpj.12712 ;  PMID:  25345491
• Jasmonic acid enhancement of anthocyanin accumulation is dependent on phytochrome A signaling pathway under far-red light in Arabidopsis.   DOI:  10.1016/j.bbrc.2014.10.059 ;  PMID:  25450360
• AtROS1 overexpression provides evidence for epigenetic regulation of genes encoding enzymes of flavonoid biosynthesis and antioxidant pathways during salt stress in transgenic tobacco.   DOI:  10.1093/jxb/erv304 ;  PMID:  26116024
• Phytochrome-interacting factors PIF4 and PIF5 negatively regulate anthocyanin biosynthesis under red light in Arabidopsis seedlings.   DOI:  10.1016/j.plantsci.2015.06.001 ;  PMID:  26259175
• Endogenous Arabidopsis messenger RNAs transported to distant tissues.   DOI:  10.1038/nplants.2015.25 ;  PMID:  27247031
• The Arabidopsis Transcription Factor ANAC032 Represses Anthocyanin Biosynthesis in Response to High Sucrose and Oxidative and Abiotic Stresses.   DOI:  10.3389/fpls.2016.01548 ;  PMID:  27790239
• Calmodulin-binding protein CBP60g functions as a negative regulator in Arabidopsis anthocyanin accumulation.   DOI:  10.1371/journal.pone.0173129 ;  PMID:  28253311
• GA-DELLA pathway is involved in regulation of nitrogen deficiency-induced anthocyanin accumulation.   DOI:  10.1007/s00299-017-2102-7 ;  PMID:  28275852
• Protective role of anthocyanins in plants under low nitrogen stress.   DOI:  10.1016/j.bbrc.2018.03.087 ;  PMID:  29548824
• The Peroxidative Cleavage of Kaempferol Contributes to the Biosynthesis of the Benzenoid Moiety of Ubiquinone in Plants.   DOI:  10.1105/tpc.18.00688 ;  PMID:  30429224
• Diversity of genetic lesions characterizes new Arabidopsis flavonoid pigment mutant alleles from T-DNA collections.   DOI:  10.1016/j.plantsci.2019.110335 ;  PMID:  31928687
• SPX4 interacts with both PHR1 and PAP1 to regulate critical steps in phosphorus-status-dependent anthocyanin biosynthesis.   DOI:  10.1111/nph.17139 ;  PMID:  33617039
• Fibrillin2 in chloroplast plastoglobules participates in photoprotection and jasmonate-induced senescence.   DOI:  10.1093/plphys/kiac166 ;  PMID:  35404409
• MYB3 plays an important role in lignin and anthocyanin biosynthesis under salt stress condition in Arabidopsis.   DOI:  10.1007/s00299-022-02878-7 ;  PMID:  35562569
• PHR1 positively regulates phosphate starvation-induced anthocyanin accumulation through direct upregulation of genes F3'H and LDOX in Arabidopsis.   DOI:  10.1007/s00425-022-03952-w ;  PMID:  35842503
• Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations.   DOI:  10.1105/tpc.4.3.333 ;  PMID:  1354004
• Sucrose-specific induction of the anthocyanin biosynthetic pathway in Arabidopsis.   DOI:  10.1104/pp.105.072579 ;  PMID:  16384906

Sequence: