Gene Details:
- Gene ID: HORVU.MOREX.r3.1HG0046420
- Gene Symbol: HvMyo11A1|Ror1
- Gene Name:
- Genome:
- Species: Hordeum vulgare
Functional Descriptions:
- Barley HvMyo11A1|Ror1 encodes a class XI myosin required for mlo-based broad-spectrum resistance to the fungal powdery mildew pathogen.
- Single amino acid substitutions of this myosin, deduced from non-functional HvMyo11A1|Ror1 mutant alleles, map to the nucleotide-binding region and the interface between the relay-helix and the converter domain of the motor protein.
- HvMyo11A1|Ror1 myosin accumulates transiently in the course of powdery mildew infection. Functional fluorophore-labeled HvMyo11A1|Ror1 variants associate with mobile intracellular compartments that partially colocalize with peroxisomes.
- Single-cell expression of the HvMyo11A1|Ror1 tail region causes a dominant-negative effect that phenocopies HvMyo11A1|Ror1 loss-of-function mutants.
Function-related keywords:
- resistance , pathogen , pathogen-resistance , powdery-mildew , mildew-resistance , mildew , powdery-mildew-resistance , protein
Literature:
- Barley Ror1 encodes a class XI myosin required for mlo-based broad-spectrum resistance to the fungal powdery mildew pathogen. DOI: 10.1111/tpj.15930 ; PMID: 35916711
Related News:
Gene Resources:
Orthologs:
Sequences:
cDNA Sequence
- >HORVU.MOREX.r3.1HG0046420.1
ATGGCATCCATGGGCCGCTTTACAGTGGGTTCTCATGTTTGGGTCGAGGATGCTGATGTGGCTTGGATTGATGGTCTGGTGGAGGAGGTCCATGGGGATGAACTAATAATAAACTGCACTTCTGGGAAGAAGGTTACTGCAAATGTGTCAAGCGTCTATCCTAAGGATGTAGAAGTAAAACGCTGTGGTGTTGAGGATATGACAAGGCTAGCTTATCTACATGAACCAGGAGTCCTCCGGAACTTGAAGTCAAGATATGGAATGAATGAAATATATACTTATACTGGGAACATATTGATAGCTGTAAATCCGTTTCAAAGACTTCCTCACCTTTATAATGATCATATGATGGAAATGTACAAAGGAGTCGAATTTGGTGAGCTGAGTCCCCATCCTTTTGCCATGGCAGACCGTGCATATAGGCTTATGATGAATTGTGGTATCAGTCAAGCCATTTTGGTGAGTGGCGAAAGTGGAGCTGGTAAGACAGAAAGCACTAAAATGCTTATGCAATATCTTGCTTTTATGGGTGGCAAAGTTGAATCTGGTGGAAGGTCAGTGCAACAACAAGTGCTGGAGTCCAATCCTGTTCTCGAGGCATTTGGAAATGCAAAAACAGTCAGGAATAATAATTCAAGTCGTTTCGGCAAATTTGTTGAGCTTCAGTTTGATCAGACTGGGAAGATCTCAGGAGCTGCTATAAGGACTTACCTTTTGGAAAGATCTCGCGTCTGTCAAATATCTGACCCAGAAAGAAATTATCACTGCTTTTACATGCTATGTGCTGCGCCACCAGAGGACCGTGAGAGATATAAATTGGGAGATGCCTCATTGTTTCATTATCTCAATCAGTCTAACTGCATTAAGCTTGATGGAATGGATGATTCTTCAGAATATATAGCAACCAGGAGAGCAATGGATATTGTAGGCATTAGTTTTGATGAGCAGGATGCCATATTCAGAGTTGTAGCTGCTATTCTTCATCTGGGCAATGTGGAATTTTCAGAAGGGAGCGAAGAAGATTCTTCTGTACCCAAAGATGACAAATCCCAGTTCCATCTCCGGACAGCTGCGGAGCTTTTCATGTGTGATGAAAAGTCTCTGGAGGAATCTTTATGTAAGCGTGTTATGGTAACACGTGGTGAGAGTATTGTAAGAAACTTGGATTCACGAGCAGCAGCTCTTAGTAGAGATGCATTGGCCAGAATCGTTTACTCCCGTTTGTTTGATTGGCTTGTGAATAAGATCAATACGACAATAGGACAGGATCCTACTTCAAAGCTTTTGATCGGTGTGCTGGATATTTATGGATTTGAAAGTTTCAAGACAAACAGTTTCGAACAGTTCTGTATCAACTTAACCAATGAGAAGCTCCAGCAACACTTCAATCAGCATGTTTTTAAGATGGAGCAAGAAGAATATACAAAAGAAGAGATTGATTGGAGTTACATCCAGTTTGTGGACAACCAAGAGATTCTTGATCTCATTGAGAAGAAACCAGGGGGGATAATTGCTCTACTGGATGAGACTTGCATGTTGCGAAATTCGAACCATGAAACATTCGCTGAAAAGCTATATCAAAAATTCAAGGACAATCCACACTTCAGCAGGCCAAAATTTTCACGGTCTGATTTTACTATTCATCACTATGCGGGAAATGTTACATACCAAACGGATCTATTCTTAGATAAGAACATAGATTATGCTGTAAACGAGCATCAAGATTTGTTACATGCTTCTACATGTCCATTTGTTTCAAGTCTTTTTCCTCTTTCTGAAGAATCGACTAAATCGAGTAAATCCACAAAGTTCACATCAATAGGTTCGAGCTTTAAGCAACAATTACAAGGTTTGTTGGAAACTCTCAGCGCAACAGAACCACATTACATGCGCTGCATAAAGCCTAATAATGTTCTCAAACCAGCAATTTTTGAGAACAGTAATGTTCTCCAGCAACTTCGATGTGGGGGGGTGCTAGAGGCAATAAGAATAAGCTGTCTAGGATATCCGACAAGGCGGACATTTGAAGAATTTGTTGATCGCTTTAGTGTTTTACGACCAGAAGTTCTTGGTTTATGTCATGATGAAGTTACTGCCACAAACATGCTCCTTGAGAAAGTAAATCTCACAGGTTATCAGATAGGGAAAACAAAAGTGTTTCTGCGTGCTGGTCAGATGGCTGAATTAGATGCTCGGAGGACTGAGGTCTTGAGCTATTCTGCTAGTAAAATCCAGCGAAAAGTTCGGTCGTTCCTGGCTCGCAGAAATTTCATTCAGCTGCGAATGTCTTCTGTTCAGCTTCAGGCAATGTGCAGAGGACAAATTGCAAGGCATTATTATGAAGATCTCCGTAGGAAGGCGGCTTCATTAAAAATTCAGACCTACTATCGTATGCACTTTGCAAGGAAAAACTACAAAGATCTCTATTCTGCATCAACTACTATACAATCAGGTCTACGTGGTATAGCTGCTCGCAATGAACTTCATTTCCGTCAGCAAACAAAAGCGGCAGTGATTATTCAGAGTTGCTGCCGTAGTGATTTAGCAAGCTCACGGTACATGGGCTTAAAGAAGGCAGCGATTACAACCCAGTGTGCTTGGAGAGGAAGGGTGGCCAGAAGAGAACTTAGAAAACTTAAAATGGCTGCAAAAGAAAGTGGTGCTCTGCAAGCTGCAAAGAATAAGTTGGAGAAGCAAGTTGAGGAGCTCACTTGGCGGTTGCAACTGGAGAAACGCATGAGGACCGACATGGAAGAAGCCAAGACACAAGAAAATAAGAAGTTGCAACAACAATTACAGGAATTGCAATTCCAGTCCAAGGAGACAAAAGATATATTAAGAAGGGAACAGGAAAATGCAAAAACAGCATTGGAGAAAGCTGCCTTAGTACCAGAGATCCAAGTTGATACAACTCATGTTGACAGGCTTACTGCTGAAAATGAGAATCTTAAGACACTGGTGGTTTCTCTCGAGACAAAAATTGATGAAACAGAACAGAAGTTTGAAGAAATGAAGAAAGCCAGAGAAGAATTGCTGAAGAAAGCTACAGATGCCGAGTCAAAGATAAATGGACTGACCAACACAATGCTAAGTTTTCAAGAAAAGTTGACTAATATGGAAGCTGAAAATCAACTTCTCCGGAAGCAGGCTATGTTGCATTCTAGTCTGAAAACAATATCTGAGAATACTTCTCCCAAATCTAATTCGACTAATGGCAGCCCACACTATGAGGAACAGATGACACCTCATGGCACTCCTCGAGCACCCAAGGATTATGGGAACTTCGCACATCCAAGGGCATCCTTTTCTGAGAGGCAGCATGAGAGTGTGGATACACTTATAAACTGTGTTACTGAAAATATTGGCTTTAGCGAAGGAAAACCAGTTGCTGCAATAACCATATACAAATGTCTTGTTCACTGGAAGATCTTTGAAACAGAAAAAACATCTGTTTTTGATAGGCTTATTCAAATTTTTGGTTCGGCGATGCAGTATCATGATAGCAATGAGGATCTTGCATACTGGCTATCGAACTCATCGACTTTATTGATTATACTACAAAAGAGCCTAAAAGCTGTTGGCTCAACCGGAACCACTCCACATAAAAGACCACAGAGTCAGTCATCGTTCCTTGGGAGGATGGTATTTCGTTCTTCCACCATTACTGTCGATATGGATCTTGTGCGTCAAATCGAAGCCAAGTATCCTGCATTTCTTTTCAAGCAGCAACTTACAGCATTTGTGGAAGGCTTATATGGAATGATCCGTGACAATGTCAAGAAAGAATTATCTGCATTGCTCTTGCATGCTATTCAGGTCCCGAGAATTATGAAAGCCAGTATGGTAAGACGTTCATTTGGGTCATCAAGTTTGAGGGGGCGTTCATTTTCAAATCAAGGTAGCTATTGGCTGGCGATAGTTGACAATTTGAATGAACTCTTGAATATCTTGCGAGAAAATTGTGTCCCTGCTATTTTTATTCGGAAGATATTTACCCAGATTTTCTCATTTATCAATGCTCAACTTTTCAATAGTCTACTTGTGCGCCATGAGTGCTGCTCTTTTAGCAATGGAGAATATGTAAAACAAGGATTGGCACAACTAGAGGTGTGGTGTGGAGAAGTGAAACCAGAGTATGCAGGATCTGCATTGCATGAACTCAGGCACATAAGGCAAGGTGTTGGTTTCTTGGTCATATTCAAGAAGTTCAGAATTTCATATGATGAGATAGTCAATGATCTCTGCCCAGTGCTAAGTGTCCAGCAGCTCTACAAAATATGCACACAGTACTGGGATGACAAATATAACACAGAGAGTGTATCTGAAGAAGTTCTTGATGAAATGAGAACTTTGATGACAAAGGAATCGGACCATAATGCTTCAGAGGGTGCCTTTTTACTGGATGATGAAATAAGCATGCCGATATCACTTGAGGAGATAGCAGATTCCATGGATGTTAAGGAATTTCAAAACGTGGCCCCACCATCAGAACTCGTCGCAATGTCTGCCTTCCAGTTCTTGAAAAGTTGACCAGGCCCTCTTCCCAATTCTTGAAAAGCTGATCGAGCCCTCCAAGATGCTGTCTGTTCATTCCCTTGGACATGTTCTGCTGAACTGTGCCAGCAGATCTATGTATTCTTCCTCATCAATGTTGTAAATTCAACCTAGGGTTTCCCTTCTGCCCTGCAGTTATGTTGTGCCATGTAAATCATCATTCTTTCCTAGATAGATTGGTCTTTTCTCCCAATTTTTTGTTGGCTGGGTTGGGAATAATTTCTTCACCCTCCCAAATCCCCGTCACAAAAAGAGTGGAGTAATTCATTCTTTGTAGCATATAGAACAAAGAGCGACACCTACACCATGTCTATCCATATTCTGTCATATTTGATGTGAATAACTGTATAGTTTAACATAATTTTTTCTTCAATTC
CDS Sequence
- >HORVU.MOREX.r3.1HG0046420.1
ATGGCATCCATGGGCCGCTTTACAGTGGGTTCTCATGTTTGGGTCGAGGATGCTGATGTGGCTTGGATTGATGGTCTGGTGGAGGAGGTCCATGGGGATGAACTAATAATAAACTGCACTTCTGGGAAGAAGGTTACTGCAAATGTGTCAAGCGTCTATCCTAAGGATGTAGAAGTAAAACGCTGTGGTGTTGAGGATATGACAAGGCTAGCTTATCTACATGAACCAGGAGTCCTCCGGAACTTGAAGTCAAGATATGGAATGAATGAAATATATACTTATACTGGGAACATATTGATAGCTGTAAATCCGTTTCAAAGACTTCCTCACCTTTATAATGATCATATGATGGAAATGTACAAAGGAGTCGAATTTGGTGAGCTGAGTCCCCATCCTTTTGCCATGGCAGACCGTGCATATAGGCTTATGATGAATTGTGGTATCAGTCAAGCCATTTTGGTGAGTGGCGAAAGTGGAGCTGGTAAGACAGAAAGCACTAAAATGCTTATGCAATATCTTGCTTTTATGGGTGGCAAAGTTGAATCTGGTGGAAGGTCAGTGCAACAACAAGTGCTGGAGTCCAATCCTGTTCTCGAGGCATTTGGAAATGCAAAAACAGTCAGGAATAATAATTCAAGTCGTTTCGGCAAATTTGTTGAGCTTCAGTTTGATCAGACTGGGAAGATCTCAGGAGCTGCTATAAGGACTTACCTTTTGGAAAGATCTCGCGTCTGTCAAATATCTGACCCAGAAAGAAATTATCACTGCTTTTACATGCTATGTGCTGCGCCACCAGAGGACCGTGAGAGATATAAATTGGGAGATGCCTCATTGTTTCATTATCTCAATCAGTCTAACTGCATTAAGCTTGATGGAATGGATGATTCTTCAGAATATATAGCAACCAGGAGAGCAATGGATATTGTAGGCATTAGTTTTGATGAGCAGGATGCCATATTCAGAGTTGTAGCTGCTATTCTTCATCTGGGCAATGTGGAATTTTCAGAAGGGAGCGAAGAAGATTCTTCTGTACCCAAAGATGACAAATCCCAGTTCCATCTCCGGACAGCTGCGGAGCTTTTCATGTGTGATGAAAAGTCTCTGGAGGAATCTTTATGTAAGCGTGTTATGGTAACACGTGGTGAGAGTATTGTAAGAAACTTGGATTCACGAGCAGCAGCTCTTAGTAGAGATGCATTGGCCAGAATCGTTTACTCCCGTTTGTTTGATTGGCTTGTGAATAAGATCAATACGACAATAGGACAGGATCCTACTTCAAAGCTTTTGATCGGTGTGCTGGATATTTATGGATTTGAAAGTTTCAAGACAAACAGTTTCGAACAGTTCTGTATCAACTTAACCAATGAGAAGCTCCAGCAACACTTCAATCAGCATGTTTTTAAGATGGAGCAAGAAGAATATACAAAAGAAGAGATTGATTGGAGTTACATCCAGTTTGTGGACAACCAAGAGATTCTTGATCTCATTGAGAAGAAACCAGGGGGGATAATTGCTCTACTGGATGAGACTTGCATGTTGCGAAATTCGAACCATGAAACATTCGCTGAAAAGCTATATCAAAAATTCAAGGACAATCCACACTTCAGCAGGCCAAAATTTTCACGGTCTGATTTTACTATTCATCACTATGCGGGAAATGTTACATACCAAACGGATCTATTCTTAGATAAGAACATAGATTATGCTGTAAACGAGCATCAAGATTTGTTACATGCTTCTACATGTCCATTTGTTTCAAGTCTTTTTCCTCTTTCTGAAGAATCGACTAAATCGAGTAAATCCACAAAGTTCACATCAATAGGTTCGAGCTTTAAGCAACAATTACAAGGTTTGTTGGAAACTCTCAGCGCAACAGAACCACATTACATGCGCTGCATAAAGCCTAATAATGTTCTCAAACCAGCAATTTTTGAGAACAGTAATGTTCTCCAGCAACTTCGATGTGGGGGGGTGCTAGAGGCAATAAGAATAAGCTGTCTAGGATATCCGACAAGGCGGACATTTGAAGAATTTGTTGATCGCTTTAGTGTTTTACGACCAGAAGTTCTTGGTTTATGTCATGATGAAGTTACTGCCACAAACATGCTCCTTGAGAAAGTAAATCTCACAGGTTATCAGATAGGGAAAACAAAAGTGTTTCTGCGTGCTGGTCAGATGGCTGAATTAGATGCTCGGAGGACTGAGGTCTTGAGCTATTCTGCTAGTAAAATCCAGCGAAAAGTTCGGTCGTTCCTGGCTCGCAGAAATTTCATTCAGCTGCGAATGTCTTCTGTTCAGCTTCAGGCAATGTGCAGAGGACAAATTGCAAGGCATTATTATGAAGATCTCCGTAGGAAGGCGGCTTCATTAAAAATTCAGACCTACTATCGTATGCACTTTGCAAGGAAAAACTACAAAGATCTCTATTCTGCATCAACTACTATACAATCAGGTCTACGTGGTATAGCTGCTCGCAATGAACTTCATTTCCGTCAGCAAACAAAAGCGGCAGTGATTATTCAGAGTTGCTGCCGTAGTGATTTAGCAAGCTCACGGTACATGGGCTTAAAGAAGGCAGCGATTACAACCCAGTGTGCTTGGAGAGGAAGGGTGGCCAGAAGAGAACTTAGAAAACTTAAAATGGCTGCAAAAGAAAGTGGTGCTCTGCAAGCTGCAAAGAATAAGTTGGAGAAGCAAGTTGAGGAGCTCACTTGGCGGTTGCAACTGGAGAAACGCATGAGGACCGACATGGAAGAAGCCAAGACACAAGAAAATAAGAAGTTGCAACAACAATTACAGGAATTGCAATTCCAGTCCAAGGAGACAAAAGATATATTAAGAAGGGAACAGGAAAATGCAAAAACAGCATTGGAGAAAGCTGCCTTAGTACCAGAGATCCAAGTTGATACAACTCATGTTGACAGGCTTACTGCTGAAAATGAGAATCTTAAGACACTGGTGGTTTCTCTCGAGACAAAAATTGATGAAACAGAACAGAAGTTTGAAGAAATGAAGAAAGCCAGAGAAGAATTGCTGAAGAAAGCTACAGATGCCGAGTCAAAGATAAATGGACTGACCAACACAATGCTAAGTTTTCAAGAAAAGTTGACTAATATGGAAGCTGAAAATCAACTTCTCCGGAAGCAGGCTATGTTGCATTCTAGTCTGAAAACAATATCTGAGAATACTTCTCCCAAATCTAATTCGACTAATGGCAGCCCACACTATGAGGAACAGATGACACCTCATGGCACTCCTCGAGCACCCAAGGATTATGGGAACTTCGCACATCCAAGGGCATCCTTTTCTGAGAGGCAGCATGAGAGTGTGGATACACTTATAAACTGTGTTACTGAAAATATTGGCTTTAGCGAAGGAAAACCAGTTGCTGCAATAACCATATACAAATGTCTTGTTCACTGGAAGATCTTTGAAACAGAAAAAACATCTGTTTTTGATAGGCTTATTCAAATTTTTGGTTCGGCGATGCAGTATCATGATAGCAATGAGGATCTTGCATACTGGCTATCGAACTCATCGACTTTATTGATTATACTACAAAAGAGCCTAAAAGCTGTTGGCTCAACCGGAACCACTCCACATAAAAGACCACAGAGTCAGTCATCGTTCCTTGGGAGGATGGTATTTCGTTCTTCCACCATTACTGTCGATATGGATCTTGTGCGTCAAATCGAAGCCAAGTATCCTGCATTTCTTTTCAAGCAGCAACTTACAGCATTTGTGGAAGGCTTATATGGAATGATCCGTGACAATGTCAAGAAAGAATTATCTGCATTGCTCTTGCATGCTATTCAGGTCCCGAGAATTATGAAAGCCAGTATGGTAAGACGTTCATTTGGGTCATCAAGTTTGAGGGGGCGTTCATTTTCAAATCAAGGTAGCTATTGGCTGGCGATAGTTGACAATTTGAATGAACTCTTGAATATCTTGCGAGAAAATTGTGTCCCTGCTATTTTTATTCGGAAGATATTTACCCAGATTTTCTCATTTATCAATGCTCAACTTTTCAATAGTCTACTTGTGCGCCATGAGTGCTGCTCTTTTAGCAATGGAGAATATGTAAAACAAGGATTGGCACAACTAGAGGTGTGGTGTGGAGAAGTGAAACCAGAGTATGCAGGATCTGCATTGCATGAACTCAGGCACATAAGGCAAGGTGTTGGTTTCTTGGTCATATTCAAGAAGTTCAGAATTTCATATGATGAGATAGTCAATGATCTCTGCCCAGTGCTAAGTGTCCAGCAGCTCTACAAAATATGCACACAGTACTGGGATGACAAATATAACACAGAGAGTGTATCTGAAGAAGTTCTTGATGAAATGAGAACTTTGATGACAAAGGAATCGGACCATAATGCTTCAGAGGGTGCCTTTTTACTGGATGATGAAATAAGCATGCCGATATCACTTGAGGAGATAGCAGATTCCATGGATGTTAAGGAATTTCAAAACGTGGCCCCACCATCAGAACTCGTCGCAATGTCTGCCTTCCAGTTCTTGAAAAGTTGA
Protein Sequence
- >HORVU.MOREX.r3.1HG0046420.1
MASMGRFTVGSHVWVEDADVAWIDGLVEEVHGDELIINCTSGKKVTANVSSVYPKDVEVKRCGVEDMTRLAYLHEPGVLRNLKSRYGMNEIYTYTGNILIAVNPFQRLPHLYNDHMMEMYKGVEFGELSPHPFAMADRAYRLMMNCGISQAILVSGESGAGKTESTKMLMQYLAFMGGKVESGGRSVQQQVLESNPVLEAFGNAKTVRNNNSSRFGKFVELQFDQTGKISGAAIRTYLLERSRVCQISDPERNYHCFYMLCAAPPEDRERYKLGDASLFHYLNQSNCIKLDGMDDSSEYIATRRAMDIVGISFDEQDAIFRVVAAILHLGNVEFSEGSEEDSSVPKDDKSQFHLRTAAELFMCDEKSLEESLCKRVMVTRGESIVRNLDSRAAALSRDALARIVYSRLFDWLVNKINTTIGQDPTSKLLIGVLDIYGFESFKTNSFEQFCINLTNEKLQQHFNQHVFKMEQEEYTKEEIDWSYIQFVDNQEILDLIEKKPGGIIALLDETCMLRNSNHETFAEKLYQKFKDNPHFSRPKFSRSDFTIHHYAGNVTYQTDLFLDKNIDYAVNEHQDLLHASTCPFVSSLFPLSEESTKSSKSTKFTSIGSSFKQQLQGLLETLSATEPHYMRCIKPNNVLKPAIFENSNVLQQLRCGGVLEAIRISCLGYPTRRTFEEFVDRFSVLRPEVLGLCHDEVTATNMLLEKVNLTGYQIGKTKVFLRAGQMAELDARRTEVLSYSASKIQRKVRSFLARRNFIQLRMSSVQLQAMCRGQIARHYYEDLRRKAASLKIQTYYRMHFARKNYKDLYSASTTIQSGLRGIAARNELHFRQQTKAAVIIQSCCRSDLASSRYMGLKKAAITTQCAWRGRVARRELRKLKMAAKESGALQAAKNKLEKQVEELTWRLQLEKRMRTDMEEAKTQENKKLQQQLQELQFQSKETKDILRREQENAKTALEKAALVPEIQVDTTHVDRLTAENENLKTLVVSLETKIDETEQKFEEMKKAREELLKKATDAESKINGLTNTMLSFQEKLTNMEAENQLLRKQAMLHSSLKTISENTSPKSNSTNGSPHYEEQMTPHGTPRAPKDYGNFAHPRASFSERQHESVDTLINCVTENIGFSEGKPVAAITIYKCLVHWKIFETEKTSVFDRLIQIFGSAMQYHDSNEDLAYWLSNSSTLLIILQKSLKAVGSTGTTPHKRPQSQSSFLGRMVFRSSTITVDMDLVRQIEAKYPAFLFKQQLTAFVEGLYGMIRDNVKKELSALLLHAIQVPRIMKASMVRRSFGSSSLRGRSFSNQGSYWLAIVDNLNELLNILRENCVPAIFIRKIFTQIFSFINAQLFNSLLVRHECCSFSNGEYVKQGLAQLEVWCGEVKPEYAGSALHELRHIRQGVGFLVIFKKFRISYDEIVNDLCPVLSVQQLYKICTQYWDDKYNTESVSEEVLDEMRTLMTKESDHNASEGAFLLDDEISMPISLEEIADSMDVKEFQNVAPPSELVAMSAFQFLKS