Gene Details:

• MSU gene ID: LOC_Os07g46450
• RAPdb gene ID: Os07g0658300
• Gene Symbol: SPIN6
• Genome: MSU7 ,  IRGSP-1.0
• Species: Oryza sativa

Functional Descriptions:

• Both RNAi silencing in transgenic rice and knockout of SPIN6 in a T-DNA insertion mutant lead to PCD and increased resistance to the rice blast pathogen Magnaporthe oryzae and the bacterial blight pathogen Xanthomonas oryzae pv.
• The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in Rice.
• Together, our results demonstrate that the RhoGAP SPIN6 acts as a linkage between a U-box E3 ligase-mediated ubiquitination pathway and a small GTPase-associated defensome system for plant immunity.
• The levels of reactive oxygen species and defense-related gene expression are significantly elevated in both the SPIN6 RNAi and mutant plants.

Function-related keywords:

• blast ,  magnaporthe-oryzae ,  blight ,  cell-death ,  PCD ,  bacterial-blight ,  resistance ,  innate-immunity ,  immunity ,  reactive-oxygen-species

Literature:

• The RhoGAP SPIN6 associates with SPL11 and OsRac1 and negatively regulates programmed cell death and innate immunity in rice .  DOI:  10.1371/journal.ppat.1004629 ;  PMID:  25658451

Related News:

Gene Resources:

• NCBI ID:
• UniProt accessions:

Sequences: