Gene Details:

Functional Descriptions:

  • In leaf tissues, mutations in SlMET1 caused CG hypomethylation and CHH hypermethylation on a whole-genome scale, leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues, which are normally expressed in fruits.
  • Report the critical function of tomato (Solanum lycopersicum) Methyltransferase 1 (SlMET1) in plant development and DNA methylome and transcriptome regulation.
  • SlMET1 is required for proper transcriptional regulation of key genes for tomato productivity.
  • Our results depict SlMET1- and tissue culture-dependent tomato DNA methylomes, and that SlMET1 is required for maintaining a normal transcriptome and normal development of tomato.

Literature:

Gene Resources:

Orthologs:

Sequences:

cDNA Sequence
  • />Solyc11g030600.3.1
    GCGAAGCAGCAAGCTGTGACCAGCAAACTCCGGCGAAGCAGCGATAACAACTCAGGCCAGCAGTGGGGCAGCAACTCCGGTTGGTGAGGATGGCGTCACCCCAACCTAATTCGGAGTCGGTATTAGAACTTCCGAACAACGACAAATCTGGACACAAAAAGAACAAACGCAAACAAGATTCTGTGTCAAAAAGGAAGGCATCTGCAACTGGTAAGAAGGAAAAGAAACAGGCTGTTTCTGAAACTATTGAGGAGCCCACTGCTGGACGTAAAAGGCCTAAGCGAGCTGCTGCCTGTTCAGATTTTAAAGAGAAATCTGTGCATTTATCAAAAAAGTCTTCAGTCATTGAAACAAAGAAGGACCATTGTGTAGACGAAGAGGATGTAGCTATTAGGTTAACTGCGGGTCTGCAAGAGTCTCAACGACCCTGTAGAAGATTAACGGATTTTGTTTTTCATAACTCAGAAGGAATACCACAACCGTTTGGAATGTCTGAGGTTGATGATCTGTTTATCAGTGGCCTCATTTTACCACTTGAGGACAGTCTTGACAAAGTAAAAGCAAAAGGAATTAGATGTGAAGGCTTTGGGCGTATTGAAGAATGGGCTATCTCTGGCTATGAAGATGGAACTCCTGTCATATGGATCTCAACTGAGACAGCTGATTATGATTGTTTAAAACCCTCAGGTAGTTATAAGAAGTTTTATGACCACTTCTTGGCCAAGGCGACGGCTTGCGTTGAGGTTTATAAGAAGCTTTCAAAGTCATCTGGAGGGAATCCTGATTTAAGTCTTGACGAGTTGCTTGCAGGGGTTGTCCGAGCGATGACTGGCATAAAATGCTTTTCAGGTGGAGTATCCATCAGGGACTTTGTCATCACTCAGGGCGGGTTCATATATAAGGAACTTATTGGTCTGGATGATACATCAAAGAAGACTGATCAACTTTTTGTTGAGCTACCTGTCCTAGCTTCCCTTAGAGATGAAAGCAGCAAGCACGAGACACTTGCACAACCAGAGACTATATCATCTGGTAATGGTCTACGTATTGGCCCAAAAGCAGGAAATGGAGGAGACAAGATAGTTGAATCTGGTTTGGCCAATGGTCCAGCGCCAGAAGATGAAGATCTAAAATTGGCTAAATTGTTGCATGAAGAGGAGTATTGGTGCTCCTTGAAGCAGAAGAAAGACCGTAATACATCTTCCTCATCCAGCAAAATATACATCAAGATCAATGAGGATGAGATTGCAAGTGATTATCCTTTACCTGCATATTACAAAACATCTAATGAAGAGACTGATGAGTATATTGTCTTTGACAGTGGGGTTGAAACATACCATATTGATGAGTTGCCTCGCAGCATGCTTCATAATTGGGCATTATACAACTCGGACTCAAGGCTAATATCTTTAGAACTGCTGCCAATGAAAGCTTGTGCTGATATTGATGTAACCATTTTTGGGTCTGGAGTGATGACTGCTGATGATGGGTCTGGCTACAATTTTGACACAGATGCTAATCATTCCTCTTCAGGTGGTTCTAGATCAGCTGAAATTGATGGAATGCCAATTTACCTGAGTGCTATAAAAGAATGGATGATTGAGTTTGGGTCCTCAATGATCTTTATATCAATTCGGACTGATATGGCCTGGTATAGGCTTGGGAAGCCATTGAAACAGTATGCTCCTTGGTACGAACCAGTCATAAAGACTGCAAGATTGGCAGTGAGCATCATTACTTTGTTAAAGGAACAGAATCGTGTGGCTAGACTTTCTTTTGGAGAAGTTATTAAAAGGGTTTCAGAGTTCAAGAAAGACCATCCTGCTTATATATCATCTAATGTAGATGCAGTGGAAAGGTATGTGGTTGTACATGGGCAAATTATTCTCCAGCAGTTTTCTGAATTTCCTGATGTAAGCATTAGGAATTGTGCATTTGCGGTTGGTCTCTCAAGGAAAATGGAAGAGAGGCACCATACAAAATGGGTGATTAAGAAGAAGAAGGTGATGCAGAGACTGGAACAGAACTTAAATCCTAGAGCATCTATGGCGCCATCTGTAAAAAGGAAAGCTATGCAGGCTACTACAACAAGGCTAATCAACAGAATCTGGGGGGAATACTATTCCAATTACTCACCCGAGGTGTCAAAGGAGGTGGCTGATTGTGAGGTGAAGGATGATGAAGAACCAGATGAGCAAGAGGAAAATGAAGAGGATGATGTTCCGGAGGAGAACTTGGATGTTCCAGAGAAAGCTCATACACCTTCTTCTACAAGAAGGCATATTAAGTCACGTTCTGACAGCAAAGAAATAAACTGGGATGGGGAATCCATAGGTAAAACAGCTTCTGGTGAACAGTTGTTTAAAAAAGCTAGAGTTCATGGACATGAGATAGCTGTTGGAGATTCAGTTCTAGTGGAACATGATGAACCAGATGAGCTTCCTTCTATTTACTTTGTTGAATACATGTTTGAAAAATTGGATGGTAGCAAAATGCTTCATGGAAAAATGATGCAACGAGGATCTGACACTGTACTTGGAAATGCAGCTAATGAGAGAGAGGTATTTTTGATCAATGAATGCATGAATCTGCAACTAGGAGATGTCAAAGAAAGTATAGCTGTCAATATCAGAATGATGCCTTGGGGACACCAGCATAGAAACACGAATGCTGATAAACTTGAAAGAGCAAAAGCAGAAGACAGAAAGAGGAAGGGATTGCCGACGGAATTTTACTGCAAAAGCTTTTATCGCCCTGAAAAAGGTGCTTTTTTCAGACTCCCGTTTGATAAGATGGGCCTTGGTAATGGTTTATGCTACTCTTGTGAGTTGCAGCAAACTGATCAGGAAAAGGAATCCTTTAAGTTTGATATGTCCAAATCCAGTTTTGTATATCTGGGGACTGAGTATTCAGTTGATGACTTTGTTTATGTAAGCCCCGATCACTTTACTGCAGAAAGAGGGGGAAATGGAACTTTCAAAGCCGGAAGAAATGTGGGGTTGATGGCCTATGTAGTATGTCAATTACTAGAAATTGTTGGACCTAAGGGATCTAAACAAGCTAAAGTAGATTCTACAAATGTTAAAGTCAGAAGATTCTTCAGACCAGAGGATATATCTTCAGATAAGGCATACTCTTCTGATATCCGGGAGATCTATTACAGTGAAGATATACATACAGTTCCTGTGGAAATAATCAAAGGAAAATGTGAAGTGAGGAAGAAGTATGATATTTCCTCTGAAGATGTCCCTGCCATGTTCGACCATATTTTCTTTTGTGAATATTTGTATGATCCATTGAATGGATCCCTTAAGAAGTTACCAGCTCAGATAAACCTGAGATTGTCAAAAATTAAGCTAGATGACGCAACATCTAGGAAGAGGAAGGGGAAGGGAAAAGAAGGAGTGGATGAAGTTGGGGAACTAAATGAAACTTCTCCACAGAATCGTTTGTCCACATTAGATATCTTTGCTGGTTGTGGTGGCTTGTCTGAGGGGTTGCAGCATTCGGGTGTCACAGATACAAATTGGGCAATTGAATACGAAGCGCCTGCTGGAGATGCATTTAGACTTAATCATCCAAAGACAAAGGTGTTCATACATAATTGCAATGTGATTTTGAGGGCTGTCATGCAGAAGTGTGGAGATTCTGATGACTGTATCTCAACTCCAGAGGCTTCTGAATTAGCTGCAGCAATGGATGAGAGCGAACTGAATAGTTTGCCACTGCCTGGACAAGTTGATTTCATTAATGGAGGCCCTCCTTGTCAGGGGTTTTCTGGAATGAATAGATTTAATCAGAGCACCTGGAGTAAAGTACAGTGTGAGATGATTCTGGCATTTTTATCCTTTGCTGATTATTATCGGCCCAAGTTTTTTCTCTTGGAGAATGTTAGGAATTTTGTTTCGTTCAACCAAAAACAAACATTTCGCTTAACTGTTGCTTCCCTTCTTGAGATGGGTTATCAGGTTAGGTTTGGTATCCTTGAAGCCGGAGCGTATGGAGTTCCTCAGTCTAGGAAGAGAGCATTTATCTGGGCTGCCTCCCCAGAGGAGGTTCTTCCAGAGTGGCCAGAACCAATGCATGTTTTTGCTGTCCCAGAATTAAAAATCGCATTATCTGAAACTTCATACTATGCAGCTGTGAGGAGTACTGCTAGTGGAGCTCCATTCCGTTCACTTACTGTCAGAGACACAATTGGAGATCTTCCTGTTGTTGGCAATGGGGCAAGCAAGACTTGCATAGAGTATCAAGGTGATCCAGTATCCTGGTTCCAAAAGAAAATCCGGGGCAGCTCAATAACATTATCTGATCACATTTCAAAAGAGATGAATGAGCTTAACCTAATCAGGTGCCAAAGAATCCCCAAGCGGCCAGGAGCTGATTGGCGTGACCTTGAAGATGAAAAGGTTAAACTATCTAATGGTCAACTAGTTGATTTGATTCCATGGTGCCTGCCTAACACTGCTAAGCGGCACAACCAGTGGAAGGGGCTCTTTGGAAGGTTGGATTGGGATGGGAACTTCCCCACTTCTATTACTGATCCCCAGCCGATGGGCAAGGTGGGGATGTGCTTTCATCCAGATCAAGACAGGATTGTTACAGTTCGTGAATGTGCACGTTCTCAAGGTTTCCCAGACAGCTACCAATTTGCTGGTAACATCTTGCACAAGCACAGGCAAATAGGAAATGCTGTTCCACCTCCTTTGGCATATGCGCTTGGAAGAAAACTCAAAGAAGCTGTTGAGAGCAAAAATAGGCTCACTTAGAACTTTTTTAAGCTGTGAATTTTACATGCATGTCAATTACCATTCACATTGCCAAATTATATCAGTTACTCATTTATTAAATTTGCAGTTTCACCTATAACCCTCTATTTAGAGGTTGGGTTCAAACAAAATTGATTAAAACATTACTACCCCATTTTCATGTATGTAGCAGTATTTATGGTGTCGTTTTGCCTTAAAAAAATCAAATCTTCCATCCTATTATGTTATATT
CDS Sequence
  • />Solyc11g030600.3.1
    ATGGCGTCACCCCAACCTAATTCGGAGTCGGTATTAGAACTTCCGAACAACGACAAATCTGGACACAAAAAGAACAAACGCAAACAAGATTCTGTGTCAAAAAGGAAGGCATCTGCAACTGGTAAGAAGGAAAAGAAACAGGCTGTTTCTGAAACTATTGAGGAGCCCACTGCTGGACGTAAAAGGCCTAAGCGAGCTGCTGCCTGTTCAGATTTTAAAGAGAAATCTGTGCATTTATCAAAAAAGTCTTCAGTCATTGAAACAAAGAAGGACCATTGTGTAGACGAAGAGGATGTAGCTATTAGGTTAACTGCGGGTCTGCAAGAGTCTCAACGACCCTGTAGAAGATTAACGGATTTTGTTTTTCATAACTCAGAAGGAATACCACAACCGTTTGGAATGTCTGAGGTTGATGATCTGTTTATCAGTGGCCTCATTTTACCACTTGAGGACAGTCTTGACAAAGTAAAAGCAAAAGGAATTAGATGTGAAGGCTTTGGGCGTATTGAAGAATGGGCTATCTCTGGCTATGAAGATGGAACTCCTGTCATATGGATCTCAACTGAGACAGCTGATTATGATTGTTTAAAACCCTCAGGTAGTTATAAGAAGTTTTATGACCACTTCTTGGCCAAGGCGACGGCTTGCGTTGAGGTTTATAAGAAGCTTTCAAAGTCATCTGGAGGGAATCCTGATTTAAGTCTTGACGAGTTGCTTGCAGGGGTTGTCCGAGCGATGACTGGCATAAAATGCTTTTCAGGTGGAGTATCCATCAGGGACTTTGTCATCACTCAGGGCGGGTTCATATATAAGGAACTTATTGGTCTGGATGATACATCAAAGAAGACTGATCAACTTTTTGTTGAGCTACCTGTCCTAGCTTCCCTTAGAGATGAAAGCAGCAAGCACGAGACACTTGCACAACCAGAGACTATATCATCTGGTAATGGTCTACGTATTGGCCCAAAAGCAGGAAATGGAGGAGACAAGATAGTTGAATCTGGTTTGGCCAATGGTCCAGCGCCAGAAGATGAAGATCTAAAATTGGCTAAATTGTTGCATGAAGAGGAGTATTGGTGCTCCTTGAAGCAGAAGAAAGACCGTAATACATCTTCCTCATCCAGCAAAATATACATCAAGATCAATGAGGATGAGATTGCAAGTGATTATCCTTTACCTGCATATTACAAAACATCTAATGAAGAGACTGATGAGTATATTGTCTTTGACAGTGGGGTTGAAACATACCATATTGATGAGTTGCCTCGCAGCATGCTTCATAATTGGGCATTATACAACTCGGACTCAAGGCTAATATCTTTAGAACTGCTGCCAATGAAAGCTTGTGCTGATATTGATGTAACCATTTTTGGGTCTGGAGTGATGACTGCTGATGATGGGTCTGGCTACAATTTTGACACAGATGCTAATCATTCCTCTTCAGGTGGTTCTAGATCAGCTGAAATTGATGGAATGCCAATTTACCTGAGTGCTATAAAAGAATGGATGATTGAGTTTGGGTCCTCAATGATCTTTATATCAATTCGGACTGATATGGCCTGGTATAGGCTTGGGAAGCCATTGAAACAGTATGCTCCTTGGTACGAACCAGTCATAAAGACTGCAAGATTGGCAGTGAGCATCATTACTTTGTTAAAGGAACAGAATCGTGTGGCTAGACTTTCTTTTGGAGAAGTTATTAAAAGGGTTTCAGAGTTCAAGAAAGACCATCCTGCTTATATATCATCTAATGTAGATGCAGTGGAAAGGTATGTGGTTGTACATGGGCAAATTATTCTCCAGCAGTTTTCTGAATTTCCTGATGTAAGCATTAGGAATTGTGCATTTGCGGTTGGTCTCTCAAGGAAAATGGAAGAGAGGCACCATACAAAATGGGTGATTAAGAAGAAGAAGGTGATGCAGAGACTGGAACAGAACTTAAATCCTAGAGCATCTATGGCGCCATCTGTAAAAAGGAAAGCTATGCAGGCTACTACAACAAGGCTAATCAACAGAATCTGGGGGGAATACTATTCCAATTACTCACCCGAGGTGTCAAAGGAGGTGGCTGATTGTGAGGTGAAGGATGATGAAGAACCAGATGAGCAAGAGGAAAATGAAGAGGATGATGTTCCGGAGGAGAACTTGGATGTTCCAGAGAAAGCTCATACACCTTCTTCTACAAGAAGGCATATTAAGTCACGTTCTGACAGCAAAGAAATAAACTGGGATGGGGAATCCATAGGTAAAACAGCTTCTGGTGAACAGTTGTTTAAAAAAGCTAGAGTTCATGGACATGAGATAGCTGTTGGAGATTCAGTTCTAGTGGAACATGATGAACCAGATGAGCTTCCTTCTATTTACTTTGTTGAATACATGTTTGAAAAATTGGATGGTAGCAAAATGCTTCATGGAAAAATGATGCAACGAGGATCTGACACTGTACTTGGAAATGCAGCTAATGAGAGAGAGGTATTTTTGATCAATGAATGCATGAATCTGCAACTAGGAGATGTCAAAGAAAGTATAGCTGTCAATATCAGAATGATGCCTTGGGGACACCAGCATAGAAACACGAATGCTGATAAACTTGAAAGAGCAAAAGCAGAAGACAGAAAGAGGAAGGGATTGCCGACGGAATTTTACTGCAAAAGCTTTTATCGCCCTGAAAAAGGTGCTTTTTTCAGACTCCCGTTTGATAAGATGGGCCTTGGTAATGGTTTATGCTACTCTTGTGAGTTGCAGCAAACTGATCAGGAAAAGGAATCCTTTAAGTTTGATATGTCCAAATCCAGTTTTGTATATCTGGGGACTGAGTATTCAGTTGATGACTTTGTTTATGTAAGCCCCGATCACTTTACTGCAGAAAGAGGGGGAAATGGAACTTTCAAAGCCGGAAGAAATGTGGGGTTGATGGCCTATGTAGTATGTCAATTACTAGAAATTGTTGGACCTAAGGGATCTAAACAAGCTAAAGTAGATTCTACAAATGTTAAAGTCAGAAGATTCTTCAGACCAGAGGATATATCTTCAGATAAGGCATACTCTTCTGATATCCGGGAGATCTATTACAGTGAAGATATACATACAGTTCCTGTGGAAATAATCAAAGGAAAATGTGAAGTGAGGAAGAAGTATGATATTTCCTCTGAAGATGTCCCTGCCATGTTCGACCATATTTTCTTTTGTGAATATTTGTATGATCCATTGAATGGATCCCTTAAGAAGTTACCAGCTCAGATAAACCTGAGATTGTCAAAAATTAAGCTAGATGACGCAACATCTAGGAAGAGGAAGGGGAAGGGAAAAGAAGGAGTGGATGAAGTTGGGGAACTAAATGAAACTTCTCCACAGAATCGTTTGTCCACATTAGATATCTTTGCTGGTTGTGGTGGCTTGTCTGAGGGGTTGCAGCATTCGGGTGTCACAGATACAAATTGGGCAATTGAATACGAAGCGCCTGCTGGAGATGCATTTAGACTTAATCATCCAAAGACAAAGGTGTTCATACATAATTGCAATGTGATTTTGAGGGCTGTCATGCAGAAGTGTGGAGATTCTGATGACTGTATCTCAACTCCAGAGGCTTCTGAATTAGCTGCAGCAATGGATGAGAGCGAACTGAATAGTTTGCCACTGCCTGGACAAGTTGATTTCATTAATGGAGGCCCTCCTTGTCAGGGGTTTTCTGGAATGAATAGATTTAATCAGAGCACCTGGAGTAAAGTACAGTGTGAGATGATTCTGGCATTTTTATCCTTTGCTGATTATTATCGGCCCAAGTTTTTTCTCTTGGAGAATGTTAGGAATTTTGTTTCGTTCAACCAAAAACAAACATTTCGCTTAACTGTTGCTTCCCTTCTTGAGATGGGTTATCAGGTTAGGTTTGGTATCCTTGAAGCCGGAGCGTATGGAGTTCCTCAGTCTAGGAAGAGAGCATTTATCTGGGCTGCCTCCCCAGAGGAGGTTCTTCCAGAGTGGCCAGAACCAATGCATGTTTTTGCTGTCCCAGAATTAAAAATCGCATTATCTGAAACTTCATACTATGCAGCTGTGAGGAGTACTGCTAGTGGAGCTCCATTCCGTTCACTTACTGTCAGAGACACAATTGGAGATCTTCCTGTTGTTGGCAATGGGGCAAGCAAGACTTGCATAGAGTATCAAGGTGATCCAGTATCCTGGTTCCAAAAGAAAATCCGGGGCAGCTCAATAACATTATCTGATCACATTTCAAAAGAGATGAATGAGCTTAACCTAATCAGGTGCCAAAGAATCCCCAAGCGGCCAGGAGCTGATTGGCGTGACCTTGAAGATGAAAAGGTTAAACTATCTAATGGTCAACTAGTTGATTTGATTCCATGGTGCCTGCCTAACACTGCTAAGCGGCACAACCAGTGGAAGGGGCTCTTTGGAAGGTTGGATTGGGATGGGAACTTCCCCACTTCTATTACTGATCCCCAGCCGATGGGCAAGGTGGGGATGTGCTTTCATCCAGATCAAGACAGGATTGTTACAGTTCGTGAATGTGCACGTTCTCAAGGTTTCCCAGACAGCTACCAATTTGCTGGTAACATCTTGCACAAGCACAGGCAAATAGGAAATGCTGTTCCACCTCCTTTGGCATATGCGCTTGGAAGAAAACTCAAAGAAGCTGTTGAGAGCAAAAATAGGCTCACTTAG
Protein Sequence
  • />Solyc11g030600.3.1
    MASPQPNSESVLELPNNDKSGHKKNKRKQDSVSKRKASATGKKEKKQAVSETIEEPTAGRKRPKRAAACSDFKEKSVHLSKKSSVIETKKDHCVDEEDVAIRLTAGLQESQRPCRRLTDFVFHNSEGIPQPFGMSEVDDLFISGLILPLEDSLDKVKAKGIRCEGFGRIEEWAISGYEDGTPVIWISTETADYDCLKPSGSYKKFYDHFLAKATACVEVYKKLSKSSGGNPDLSLDELLAGVVRAMTGIKCFSGGVSIRDFVITQGGFIYKELIGLDDTSKKTDQLFVELPVLASLRDESSKHETLAQPETISSGNGLRIGPKAGNGGDKIVESGLANGPAPEDEDLKLAKLLHEEEYWCSLKQKKDRNTSSSSSKIYIKINEDEIASDYPLPAYYKTSNEETDEYIVFDSGVETYHIDELPRSMLHNWALYNSDSRLISLELLPMKACADIDVTIFGSGVMTADDGSGYNFDTDANHSSSGGSRSAEIDGMPIYLSAIKEWMIEFGSSMIFISIRTDMAWYRLGKPLKQYAPWYEPVIKTARLAVSIITLLKEQNRVARLSFGEVIKRVSEFKKDHPAYISSNVDAVERYVVVHGQIILQQFSEFPDVSIRNCAFAVGLSRKMEERHHTKWVIKKKKVMQRLEQNLNPRASMAPSVKRKAMQATTTRLINRIWGEYYSNYSPEVSKEVADCEVKDDEEPDEQEENEEDDVPEENLDVPEKAHTPSSTRRHIKSRSDSKEINWDGESIGKTASGEQLFKKARVHGHEIAVGDSVLVEHDEPDELPSIYFVEYMFEKLDGSKMLHGKMMQRGSDTVLGNAANEREVFLINECMNLQLGDVKESIAVNIRMMPWGHQHRNTNADKLERAKAEDRKRKGLPTEFYCKSFYRPEKGAFFRLPFDKMGLGNGLCYSCELQQTDQEKESFKFDMSKSSFVYLGTEYSVDDFVYVSPDHFTAERGGNGTFKAGRNVGLMAYVVCQLLEIVGPKGSKQAKVDSTNVKVRRFFRPEDISSDKAYSSDIREIYYSEDIHTVPVEIIKGKCEVRKKYDISSEDVPAMFDHIFFCEYLYDPLNGSLKKLPAQINLRLSKIKLDDATSRKRKGKGKEGVDEVGELNETSPQNRLSTLDIFAGCGGLSEGLQHSGVTDTNWAIEYEAPAGDAFRLNHPKTKVFIHNCNVILRAVMQKCGDSDDCISTPEASELAAAMDESELNSLPLPGQVDFINGGPPCQGFSGMNRFNQSTWSKVQCEMILAFLSFADYYRPKFFLLENVRNFVSFNQKQTFRLTVASLLEMGYQVRFGILEAGAYGVPQSRKRAFIWAASPEEVLPEWPEPMHVFAVPELKIALSETSYYAAVRSTASGAPFRSLTVRDTIGDLPVVGNGASKTCIEYQGDPVSWFQKKIRGSSITLSDHISKEMNELNLIRCQRIPKRPGADWRDLEDEKVKLSNGQLVDLIPWCLPNTAKRHNQWKGLFGRLDWDGNFPTSITDPQPMGKVGMCFHPDQDRIVTVRECARSQGFPDSYQFAGNILHKHRQIGNAVPPPLAYALGRKLKEAVESKNRLT*