Gene Details:

• Gene ID: Zm00001eb095020
• Gene Symbol: ZmHMA32 hma3 ZmHMA ZmHMA3a IDP7895
• Gene Name: heavy metal ATPase3
• Genome: Zm-B73-REFERENCE-NAM-5.0
• Species: Zea mays

Functional Descriptions:

• Natural variations in the P-type ATPase heavy metal transporter gene ZmHMA3 control cadmium accumulation in maize grains.
• The candidate gene ZmHMA3 was identified by fine mapping and encodes a tonoplast-localized heavy metal P-type ATPase transporter. An ethyl methane sulfonate mutant analysis and an allelism test confirmed that ZmHMA3 influences maize grain Cd accumulation.
• A transposon in intron 1 of ZmHMA3 is responsible for the abnormal amino acid sequence in Mo17. Based on the natural sequence variations in the ZmHMA3 gene of diverse maize lines, four PCR-based molecular markers were developed, and these were successfully used to distinguish five haplotypes with different grain Cd contents in the GWAS panel and to predict grain Cd contents of widely used maize inbred lines and hybrids.
• ZmHMA3 encodes a tonoplast-localized P1B-type HMA transporter. According to the sequence variations of ZmHMA3, four PCR-based molecular markers were developed that can predict and well differentiate between high Cd accumulation and low Cd accumulation maize inbred lines and hybrids.

Function-related keywords:

• grain ,  atpase ,  transporter ,  cadmium ,  cadmium-accumulation ,  amino-acid-transporter ,  heavy-metal

Literature:

• Natural variations in the P-type ATPase heavy metal transporter gene ZmHMA3 control cadmium accumulation in maize grains.   DOI:  10.1093/jxb/erab254 ;  PMID:  34235535
• Differences of cadmium uptake and accumulation in roots of two maize varieties (Zea mays L.).   DOI:  10.1007/s11356-023-29340-9 ;  PMID:  37584802

Related News:

• JXB | 北京市农林科学院赵久然团队在玉米籽粒镉含量调控基因的克隆和应用方面取得重要进展

Gene Resources:

• NCBI ID: LOC103647210
• UniProt accessions: A0A3L6FW78 ,  A0A1D6EL09 ,  A0A3L6FV53

Sequences: