Gene Details:

Functional Descriptions:

  • The ZmVp14 gene was characterized from the ABA-deficient maize mutant Vp14 and is known to be regulated by salinity and osmotic stress
  • Transient alkalinization of the leaf apoplast increases mRNA abundance of viviparous 14 (vp14).
  • The present study demonstrates for the first time that the stomatal closure, elicited by the apoplastic alkalinization, is also due to a pHapo-mediated increase in the transcription of the NCED gene Vp14 in the leaf. ZmVp14 encodes the rate-limiting enzyme in ABA biosynthesis.

Literature:

Gene Resources:

Sequences:

cDNA Sequence
  • >Zm00001eb143690_T002 CTTCTTCTCCCTCTCCACCTCCTGCTTGCACTGTTCGTCTCCTCAGTAACTGCACCCACCTCCACACCTACACCCGAGAGGCGGCGGCGGCAGACACAGACACCGTCTCTCTCCTCCCTTTGTCGTCGTGTCTCTCTGCATGGAAGCCTCCGCCGGCTCGTCGCCACCGCACTCCCAAGAGAACCCGCCGGAGCACGGTGGCGACATGGGAGGGGCCCCCGCGGAGGAGATCGGAGGGGAGGCGGCGGATGATTTCATGTTCGCTGAAGACACGTTCCCCTCCCTCCCGGACTTCCCTTGCCTTTCGTCGCCGTCCAGCTCCACCTTCTCGTCCAACTCCTCGTCAAACTCCTCCAGCGCCTACACCAACACGGCAGGAAGAGCCGGCGGCGAGCCCTCCGAGCCTGCTTCGGCCGGAGAAGGGTTTGATGCGCTCGATGACATCGACCAGCTCCTCGACTTCGCGTCGCTTTCCATGCCGTGGGACTCCGAGCCGTTCCCGGGGGTTAGCATGATGCTAGAGAACGCCATGTCGGCGCCGCCGCAGCCGGTGGGCGACGGCATGAGTGAAGAGAAAGCCGTGCCGGAAGGGACCACAGGGGGAGAGGAGGCCTGCATGGATGCGTCGGAGGGGGAGGAGCTGCCGCGGTTCTTCATGGAGTGGCTCACGAGCAACCGCGAAAACATCTCGGCCGAGGATCTCCGCGGGATCCGCCTCCGCCGCTCCACCATCGAGGCCGCCGCCGCCCGGCTCGGCGGCGGGCGCCAGGGCACCATGCAGCTGCTCAAGCTCATCCTCACCTGGGTGCAGAACCACCACCTCCAGAGGAAGCGCCCGCGCGACGTGATGGAGGAGGAGGCGGGCCTGCACGTCCAGCTCCCCAGCCCGGTCGCCAACCCACCAGGATACGAGTTCCCCGCCGGCGGACAGGACATGGCCGCGGGCGGCGGCACATCTTGGATGCCCCACCAGCAGGCATTCACGCCGCCTGCTGCGTACGGCGGCGACGCGGTGTACCCGAGCGCGGCAGGCCAACAGTACTCTTTCCACCAGGGCCCCAGCACGAGCAGCGTGGTCGTGAACAGCCAACCGTTCTCCCCGCCGCCTGTGGGCGACATGCACGGCGCGAACATGGCCTGGCCGCAGCAGTACGTGCCGTTCCCACCGCCTGGGGCTTCCACGGGCTCTTACCCTATGCCGCAGCCGTTCTCCCCCGGATTCGGCGGGCAGTACGCCGGCGCCGGCGCTGGCCACCTCTCAGTGGCCCCCCAGCGCATGGCAGGCGTGGAGGCCTCGGCGACCAAGGAGGCCCGCAAGAAGCGCATGGCGAGACAGCGGCGCCTGTCCTGCCTGCAGCAGCAGCGCAGCCAGCAGCTGAGCCTGGGCCAGATCCAGGCCTCCGTCCACCTGCAGGAGCCGTCCCCTCGGTCCACGCACTCCGGCCCGGTCACGCCGTCAGCAGGCGGCTGGGGATTCTGGTCGCCGAGCAGCCAGCAGCAGGTCCAGAACCCGCTCTCCAAGTCCAATTCATCAAGGGCGCCGCCTCCCTCGCTGGAAGCGGCGGCGGTGGCGCCACAGACAAAGCCCGCGCCTGCTGGTGCTCGGCAGGACGACATTCACCACCGCCTCGCAGCGGCTTCAGATAAGCGGCAGGGCGCCAAGGCGGACAAGAACCTGCGGTTCCTGCTGCAGAAGGTGCTGAAGCAGAGCGACGTCGGGAGCCTCGGCCGCATCGTGCTCCCCAAAGAAGCGGAGGTTCACCTGCCGGAGCTGAAGACGAGGGATGGCATCTCCATCCCCATGGAGGACATCGGAACGTCGCGCGTGTGGAACATGCGGTACAGGTTTTGGCCCAACAACAAGAGCAGAATGTATCTGCTGGAGAACACAGGGGAATTTGTTCGTTCCAACGAGCTTCAGGAGGGGGATTTCATAGTGATCTACTCCGATGTCAAGTCGGGCAAATATCTGATACGGGGCGTGAAGGTAAGGCCCCCGCCGGCGCAAGAGCAAGGCAGTGGTTCCAGCGGGGGAGGCAAGCACAGGCCCCTCTGTCCAGCAGGTCCAGGGAGAGCCGCAGCCGCCGGTGCTCCTGAAGACGCCGTCGTCGACGGGGTCAGCGGCGCCTGCAAGGGGAGGTCTCCGGAAGGCGTGCGGCGGGTTCGGCAGCAGGGAGCCGGCGCCATGAGCCAGATGGCGGTGAGCATCTGAAAGAGCAGCAGACTCCGCCATATATTGATCGATCGACCAATCGATCGTTAGTTCTCCAAGTTACTATTAGCTAGCTATAGCTCGAAACAGCTGAACTGATGATGACGATGGTAACCTCCGTCGTGTGTGCTAAGCATGTAGCGTGCTAGGAGATGATATATTAAATATAATCGAGTAGTAGAGCCACCCGCTGTGTGACGCTAAATTTGTGTGCATGGTTTGGTTTGTGAGTTGGGCCCGTGCGTGGCTGTGTCATGTCGTGGTTAATTAGCTATACTAGTCCTGTCTGTACATGCATGGACATACCTGATCTCTCGGCCATTGGTGTCGGCGACGTGCCATTCGGCTAACAAGACGACAGCTGCAGCCTGCAGCAAAAGCTAGAACATTCTACAC
  • >Zm00001eb143690_T001 CTTCTTCTCCCTCTCCACCTCCTGCTTGCACTGTTCGTCTCCTCAGTAACTGCACCCACCTCCACACCTACACCCGAGAGGCGGCGGCGGCAGACACAGACACCGTCTCTCTCCTCCCTTTGTCGTCGTGTCTCTCTGCATGGAAGCCTCCGCCGGCTCGTCGCCACCGCACTCCCAAGAGAACCCGCCGGAGCACGGTGGCGACATGGGAGGGGCCCCCGCGGAGGAGATCGGAGGGGAGGCGGCGGATGATTTCATGTTCGCTGAAGACACGTTCCCCTCCCTCCCGGACTTCCCTTGCCTTTCGTCGCCGTCCAGCTCCACCTTCTCGTCCAACTCCTCGTCAAACTCCTCCAGCGCCTACACCAACACGGCAGGAAGAGCCGGCGGCGAGCCCTCCGAGCCTGCTTCGGCCGGAGAAGGGTTTGATGCGCTCGATGACATCGACCAGCTCCTCGACTTCGCGTCGCTTTCCATGCCGTGGGACTCCGAGCCGTTCCCGGGGGTTAGCATGATGCTAGAGAACGCCATGTCGGCGCCGCCGCAGCCGGTGGGCGACGGCATGAGTGAAGAGAAAGCCGTGCCGGAAGGGACCACAGGGGGAGAGGAGGCCTGCATGGATGCGTCGGAGGGGGAGGAGCTGCCGCGGTTCTTCATGGAGTGGCTCACGAGCAACCGCGAAAACATCTCGGCCGAGGATCTCCGCGGGATCCGCCTCCGCCGCTCCACCATCGAGGCCGCCGCCGCCCGGCTCGGCGGCGGGCGCCAGGGCACCATGCAGCTGCTCAAGCTCATCCTCACCTGGGTGCAGAACCACCACCTCCAGAGGAAGCGCCCGCGCGACGTGATGGAGGAGGAGGCGGGCCTGCACGTCCAGCTCCCCAGCCCGGTCGCCAACCCACCAGGATACGAGTTCCCCGCCGGCGGACAGGACATGGCCGCGGGCGGCGGCACATCTTGGATGCCCCACCAGCAGGCATTCACGCCGCCTGCTGCGTACGGCGGCGACGCGGTGTACCCGAGCGCGGCAGGCCAACAGTACTCTTTCCACCAGGGCCCCAGCACGAGCAGCGTGGTCGTGAACAGCCAACCGTTCTCCCCGCCGCCTGTGGGCGACATGCACGGCGCGAACATGGCCTGGCCGCAGCAGTACGTGCCGTTCCCACCGCCTGGGGCTTCCACGGGCTCTTACCCTATGCCGCAGCCGTTCTCCCCCGGATTCGGCGGGCAGTACGCCGGCGCCGGCGCTGGCCACCTCTCAGTGGCCCCCCAGCGCATGGCAGGCGTGGAGGCCTCGGCGACCAAGGAGGCCCGCAAGAAGCGCATGGCGAGACAGCGGCGCCTGTCCTGCCTGCAGCAGCAGCGCAGCCAGCAGCTGAGCCTGGGCCAGATCCAGGCCTCCGTCCACCTGCAGGAGCCGTCCCCTCGGTCCACGCACTCCGGCCCGGTCACGCCGTCAGCAGGCGGCTGGGGATTCTGGTCGCCGAGCAGCCAGCAGCAGGTCCAGAACCCGCTCTCCAAGTCCAATTCATCAAGGGCGCCGCCTCCCTCGCTGGAAGCGGCGGCGGTGGCGCCACAGACAAAGCCCGCGCCTGCTGGTGCTCGGCAGGACGACATTCACCACCGCCTCGCAGCGGCTTCAGATAAGCGGCAGGGCGCCAAGGCGGACAAGAACCTGCGGTTCCTGCTGCAGAAGGTGCTGAAGCAGAGCGACGTCGGGAGCCTCGGCCGCATCGTGCTCCCCAAAGAAGCGGAGGTTCACCTGCCGGAGCTGAAGACGAGGGATGGCATCTCCATCCCCATGGAGGACATCGGAACGTCGCGCGTGTGGAACATGCGGTACAGGTTTTGGCCCAACAACAAGAGCAGAATGTATCTGCTGGAGAACACAGGGGAATTTGTTCGTTCCAACGAGCTTCAGGAGGGGGATTTCATAGTGATCTACTCCGATGTCAAGTCGGGCAAATATCTGATACGGGGCGTGAAGGTAAGGCCCCCGCCGGCGCAAGAGCAAGGCAGTGGTTCCAGCGGGGGAGGCAAGCACAGGCCCCTCTGTCCAGCAGGTCCAGGGAGAGCCGCAGCCGCCGGTGCTCCTGAAGACGCCGTCGTCGACGGGGTCAGCGGCGCCTGCAAGGGGAGGTCTCCGGAAGGCGTGCGGCGGGTTCGGCAGCAGGGAGCCGGCGCCATGAGCCAGATGGCGGTGAGCATCTGAAAGAGCAGCAGACTCCGCCATATATTGATCGATCGACCAATCGATCGTTAGTTCTCCAAGTTACTATTAGCTAGCTATAGCTCGAAACAGCTGAACTGATGATGACGATGGTAACCTCCGTCGTGTGTGCTAAGCATGTAGCGTGCTAGGAGATGATATATTAAATATAATCGAGTAGTAGAGCCACCCGCTGTGTGACGCTAAATTTGTGTGCATGGTTTGGTTTGTGAGTTGGGCCCGTGCGTGGCTGTGTCATGTCGTGGTTAATTAGCTATACTAGTCCTGTCTGTACATGCATGGACATACCTGATCTCTCGGCCATTGGTGTCGGCGACGTGCCATTCGGCTAACAAGACGACAGCTGCAGCCTGCAGCAAAAGCTAGAACATTCTACAC
CDS Sequence
  • >Zm00001eb143690_T002 ATGGAAGCCTCCGCCGGCTCGTCGCCACCGCACTCCCAAGAGAACCCGCCGGAGCACGGTGGCGACATGGGAGGGGCCCCCGCGGAGGAGATCGGAGGGGAGGCGGCGGATGATTTCATGTTCGCTGAAGACACGTTCCCCTCCCTCCCGGACTTCCCTTGCCTTTCGTCGCCGTCCAGCTCCACCTTCTCGTCCAACTCCTCGTCAAACTCCTCCAGCGCCTACACCAACACGGCAGGAAGAGCCGGCGGCGAGCCCTCCGAGCCTGCTTCGGCCGGAGAAGGGTTTGATGCGCTCGATGACATCGACCAGCTCCTCGACTTCGCGTCGCTTTCCATGCCGTGGGACTCCGAGCCGTTCCCGGGGGTTAGCATGATGCTAGAGAACGCCATGTCGGCGCCGCCGCAGCCGGTGGGCGACGGCATGAGTGAAGAGAAAGCCGTGCCGGAAGGGACCACAGGGGGAGAGGAGGCCTGCATGGATGCGTCGGAGGGGGAGGAGCTGCCGCGGTTCTTCATGGAGTGGCTCACGAGCAACCGCGAAAACATCTCGGCCGAGGATCTCCGCGGGATCCGCCTCCGCCGCTCCACCATCGAGGCCGCCGCCGCCCGGCTCGGCGGCGGGCGCCAGGGCACCATGCAGCTGCTCAAGCTCATCCTCACCTGGGTGCAGAACCACCACCTCCAGAGGAAGCGCCCGCGCGACGTGATGGAGGAGGAGGCGGGCCTGCACGTCCAGCTCCCCAGCCCGGTCGCCAACCCACCAGGATACGAGTTCCCCGCCGGCGGACAGGACATGGCCGCGGGCGGCGGCACATCTTGGATGCCCCACCAGCAGGCATTCACGCCGCCTGCTGCGTACGGCGGCGACGCGGTGTACCCGAGCGCGGCAGGCCAACAGTACTCTTTCCACCAGGGCCCCAGCACGAGCAGCGTGGTCGTGAACAGCCAACCGTTCTCCCCGCCGCCTGTGGGCGACATGCACGGCGCGAACATGGCCTGGCCGCAGCAGTACGTGCCGTTCCCACCGCCTGGGGCTTCCACGGGCTCTTACCCTATGCCGCAGCCGTTCTCCCCCGGATTCGGCGGGCAGTACGCCGGCGCCGGCGCTGGCCACCTCTCAGTGGCCCCCCAGCGCATGGCAGGCGTGGAGGCCTCGGCGACCAAGGAGGCCCGCAAGAAGCGCATGGCGAGACAGCGGCGCCTGTCCTGCCTGCAGCAGCAGCGCAGCCAGCAGCTGAGCCTGGGCCAGATCCAGGCCTCCGTCCACCTGCAGGAGCCGTCCCCTCGGTCCACGCACTCCGGCCCGGTCACGCCGTCAGCAGGCGGCTGGGGATTCTGGTCGCCGAGCAGCCAGCAGCAGGTCCAGAACCCGCTCTCCAAGTCCAATTCATCAAGGGCGCCGCCTCCCTCGCTGGAAGCGGCGGCGGTGGCGCCACAGACAAAGCCCGCGCCTGCTGGTGCTCGGCAGGACGACATTCACCACCGCCTCGCAGCGGCTTCAGATAAGCGGCAGGGCGCCAAGGCGGACAAGAACCTGCGGTTCCTGCTGCAGAAGGTGCTGAAGCAGAGCGACGTCGGGAGCCTCGGCCGCATCGTGCTCCCCAAAGAAGCGGAGGTTCACCTGCCGGAGCTGAAGACGAGGGATGGCATCTCCATCCCCATGGAGGACATCGGAACGTCGCGCGTGTGGAACATGCGGTACAGGTTTTGGCCCAACAACAAGAGCAGAATGTATCTGCTGGAGAACACAGGGGAATTTGTTCGTTCCAACGAGCTTCAGGAGGGGGATTTCATAGTGATCTACTCCGATGTCAAGTCGGGCAAATATCTGATACGGGGCGTGAAGGTAAGGCCCCCGCCGGCGCAAGAGCAAGGCAGTGGTTCCAGCGGGGGAGGCAAGCACAGGCCCCTCTGTCCAGCAGGTCCAGGGAGAGCCGCAGCCGCCGGTGCTCCTGAAGACGCCGTCGTCGACGGGGTCAGCGGCGCCTGCAAGGGGAGGTCTCCGGAAGGCGTGCGGCGGGTTCGGCAGCAGGGAGCCGGCGCCATGAGCCAGATGGCGGTGAGCATCTGA
  • >Zm00001eb143690_T001 ATGGAAGCCTCCGCCGGCTCGTCGCCACCGCACTCCCAAGAGAACCCGCCGGAGCACGGTGGCGACATGGGAGGGGCCCCCGCGGAGGAGATCGGAGGGGAGGCGGCGGATGATTTCATGTTCGCTGAAGACACGTTCCCCTCCCTCCCGGACTTCCCTTGCCTTTCGTCGCCGTCCAGCTCCACCTTCTCGTCCAACTCCTCGTCAAACTCCTCCAGCGCCTACACCAACACGGCAGGAAGAGCCGGCGGCGAGCCCTCCGAGCCTGCTTCGGCCGGAGAAGGGTTTGATGCGCTCGATGACATCGACCAGCTCCTCGACTTCGCGTCGCTTTCCATGCCGTGGGACTCCGAGCCGTTCCCGGGGGTTAGCATGATGCTAGAGAACGCCATGTCGGCGCCGCCGCAGCCGGTGGGCGACGGCATGAGTGAAGAGAAAGCCGTGCCGGAAGGGACCACAGGGGGAGAGGAGGCCTGCATGGATGCGTCGGAGGGGGAGGAGCTGCCGCGGTTCTTCATGGAGTGGCTCACGAGCAACCGCGAAAACATCTCGGCCGAGGATCTCCGCGGGATCCGCCTCCGCCGCTCCACCATCGAGGCCGCCGCCGCCCGGCTCGGCGGCGGGCGCCAGGGCACCATGCAGCTGCTCAAGCTCATCCTCACCTGGGTGCAGAACCACCACCTCCAGAGGAAGCGCCCGCGCGACGTGATGGAGGAGGAGGCGGGCCTGCACGTCCAGCTCCCCAGCCCGGTCGCCAACCCACCAGGATACGAGTTCCCCGCCGGCGGACAGGACATGGCCGCGGGCGGCGGCACATCTTGGATGCCCCACCAGCAGGCATTCACGCCGCCTGCTGCGTACGGCGGCGACGCGGTGTACCCGAGCGCGGCAGGCCAACAGTACTCTTTCCACCAGGGCCCCAGCACGAGCAGCGTGGTCGTGAACAGCCAACCGTTCTCCCCGCCGCCTGTGGGCGACATGCACGGCGCGAACATGGCCTGGCCGCAGCAGTACGTGCCGTTCCCACCGCCTGGGGCTTCCACGGGCTCTTACCCTATGCCGCAGCCGTTCTCCCCCGGATTCGGCGGGCAGTACGCCGGCGCCGGCGCTGGCCACCTCTCAGTGGCCCCCCAGCGCATGGCAGGCGTGGAGGCCTCGGCGACCAAGGAGGCCCGCAAGAAGCGCATGGCGAGACAGCGGCGCCTGTCCTGCCTGCAGCAGCAGCGCAGCCAGCAGCTGAGCCTGGGCCAGATCCAGGCCTCCGTCCACCTGCAGGAGCCGTCCCCTCGGTCCACGCACTCCGGCCCGGTCACGCCGTCAGCAGGCGGCTGGGGATTCTGGTCGCCGAGCAGCCAGCAGCAGGTCCAGAACCCGCTCTCCAAGTCCAATTCATCAAGGGCGCCGCCTCCCTCGCTGGAAGCGGCGGCGGTGGCGCCACAGACAAAGCCCGCGCCTGCTGGTGCTCGGCAGGACGACATTCACCACCGCCTCGCAGCGGCTTCAGATAAGCGGCAGGGCGCCAAGGCGGACAAGAACCTGCGGTTCCTGCTGCAGAAGGTGCTGAAGCAGAGCGACGTCGGGAGCCTCGGCCGCATCGTGCTCCCCAAAGAAGCGGAGGTTCACCTGCCGGAGCTGAAGACGAGGGATGGCATCTCCATCCCCATGGAGGACATCGGAACGTCGCGCGTGTGGAACATGCGGTACAGGTTTTGGCCCAACAACAAGAGCAGAATGTATCTGCTGGAGAACACAGGGGAATTTGTTCGTTCCAACGAGCTTCAGGAGGGGGATTTCATAGTGATCTACTCCGATGTCAAGTCGGGCAAATATCTGATACGGGGCGTGAAGGTAAGGCCCCCGCCGGCGCAAGAGCAAGGCAGTGGTTCCAGCGGGGGAGGCAAGCACAGGCCCCTCTGTCCAGCAGGTCCAGGGAGAGCCGCAGCCGCCGGTGCTCCTGAAGACGCCGTCGTCGACGGGGTCAGCGGCGCCTGCAAGGGGAGGTCTCCGGAAGGCGTGCGGCGGGTTCGGCAGCAGGGAGCCGGCGCCATGAGCCAGATGGCGGTGAGCATCTGA
Protein Sequence
  • >Zm00001eb143690_P002 MEASAGSSPPHSQENPPEHGGDMGGAPAEEIGGEAADDFMFAEDTFPSLPDFPCLSSPSSSTFSSNSSSNSSSAYTNTAGRAGGEPSEPASAGEGFDALDDIDQLLDFASLSMPWDSEPFPGVSMMLENAMSAPPQPVGDGMSEEKAVPEGTTGGEEACMDASEGEELPRFFMEWLTSNRENISAEDLRGIRLRRSTIEAAAARLGGGRQGTMQLLKLILTWVQNHHLQRKRPRDVMEEEAGLHVQLPSPVANPPGYEFPAGGQDMAAGGGTSWMPHQQAFTPPAAYGGDAVYPSAAGQQYSFHQGPSTSSVVVNSQPFSPPPVGDMHGANMAWPQQYVPFPPPGASTGSYPMPQPFSPGFGGQYAGAGAGHLSVAPQRMAGVEASATKEARKKRMARQRRLSCLQQQRSQQLSLGQIQASVHLQEPSPRSTHSGPVTPSAGGWGFWSPSSQQQVQNPLSKSNSSRAPPPSLEAAAVAPQTKPAPAGARQDDIHHRLAAASDKRQGAKADKNLRFLLQKVLKQSDVGSLGRIVLPKEAEVHLPELKTRDGISIPMEDIGTSRVWNMRYRFWPNNKSRMYLLENTGEFVRSNELQEGDFIVIYSDVKSGKYLIRGVKVRPPPAQEQGSGSSGGGKHRPLCPAGPGRAAAAGAPEDAVVDGVSGACKGRSPEGVRRVRQQGAGAMSQMAVSI
  • >Zm00001eb143690_P001 MEASAGSSPPHSQENPPEHGGDMGGAPAEEIGGEAADDFMFAEDTFPSLPDFPCLSSPSSSTFSSNSSSNSSSAYTNTAGRAGGEPSEPASAGEGFDALDDIDQLLDFASLSMPWDSEPFPGVSMMLENAMSAPPQPVGDGMSEEKAVPEGTTGGEEACMDASEGEELPRFFMEWLTSNRENISAEDLRGIRLRRSTIEAAAARLGGGRQGTMQLLKLILTWVQNHHLQRKRPRDVMEEEAGLHVQLPSPVANPPGYEFPAGGQDMAAGGGTSWMPHQQAFTPPAAYGGDAVYPSAAGQQYSFHQGPSTSSVVVNSQPFSPPPVGDMHGANMAWPQQYVPFPPPGASTGSYPMPQPFSPGFGGQYAGAGAGHLSVAPQRMAGVEASATKEARKKRMARQRRLSCLQQQRSQQLSLGQIQASVHLQEPSPRSTHSGPVTPSAGGWGFWSPSSQQQVQNPLSKSNSSRAPPPSLEAAAVAPQTKPAPAGARQDDIHHRLAAASDKRQGAKADKNLRFLLQKVLKQSDVGSLGRIVLPKEAEVHLPELKTRDGISIPMEDIGTSRVWNMRYRFWPNNKSRMYLLENTGEFVRSNELQEGDFIVIYSDVKSGKYLIRGVKVRPPPAQEQGSGSSGGGKHRPLCPAGPGRAAAAGAPEDAVVDGVSGACKGRSPEGVRRVRQQGAGAMSQMAVSI